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Official Description

Hepatitis B and Haemophilus influenzae type b vaccine (Hib-HepB), for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90748 refers to a combination vaccine known as the Hepatitis B and Haemophilus influenzae type b vaccine (Hib-HepB), which is administered via intramuscular injection. This vaccine serves a critical role in public health by providing active, long-term immunity against two significant pathogens: the hepatitis B virus and the Haemophilus influenzae type b bacterium. Unlike immune globulins that offer temporary, passive immunity, vaccines like Hib-HepB stimulate the recipient's immune system to recognize and combat these pathogens effectively. By introducing altered forms of the viruses or bacteria, the vaccine prompts the immune system to produce its own antibodies, thereby establishing a memory that enables the body to respond more robustly upon future exposures to these antigens. The hepatitis B component of the vaccine is particularly important as it protects against a chronic liver disease that can lead to severe health complications, including hospitalization and mortality. Furthermore, it plays a role in preventing long-term consequences such as hepatocellular carcinoma, marking it as one of the pioneering cancer vaccines in clinical use. The vaccine can be derived from the blood plasma of asymptomatic carriers or produced through recombinant technology, where a plasmid containing the hepatitis gene is inserted into baker's yeast, followed by purification processes to isolate the active components. In addition, the Hib component of the vaccine is crucial for safeguarding children under the age of five from serious infections caused by Haemophilus influenzae type b. This bacterium can lead to severe health issues, including pneumonia, epiglottitis (serious throat swelling), osteomyelitis (infection of the bones), and meningitis, which can result in lasting neurological damage such as brain injury and hearing loss. The Hib-HepB vaccine is administered intramuscularly, and this route of administration is essential for ensuring optimal absorption and immune response.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The Hepatitis B and Haemophilus influenzae type b vaccine (Hib-HepB) is indicated for the following:

  • Protection Against Hepatitis B: The vaccine is administered to provide long-term immunity against hepatitis B, a serious liver disease that can lead to chronic infection, liver cirrhosis, and hepatocellular carcinoma.
  • Protection Against Haemophilus influenzae type b: It is indicated for the prevention of infections caused by Hib, particularly in children under the age of five, who are at a higher risk for severe complications such as pneumonia, meningitis, and other invasive diseases.

2. Procedure

The administration of the Hib-HepB vaccine involves several key procedural steps:

  • Step 1: Preparation of the Vaccine The vaccine is prepared according to the manufacturer's guidelines, ensuring that it is stored at the appropriate temperature and is not expired. The healthcare provider must inspect the vaccine for any particulate matter or discoloration before use.
  • Step 2: Patient Assessment Prior to administration, the healthcare provider should assess the patient’s medical history, including any previous allergic reactions to vaccines, current health status, and any contraindications to vaccination.
  • Step 3: Site Selection The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for older children and adults, or in the anterolateral thigh for infants and young children. The site should be cleaned with an antiseptic wipe to reduce the risk of infection.
  • Step 4: Administration of the Vaccine Using a sterile syringe and needle, the healthcare provider injects the vaccine into the selected muscle site. The injection should be performed swiftly and smoothly to minimize discomfort.
  • Step 5: Post-Administration Care After the vaccine is administered, the healthcare provider should observe the patient for a brief period to monitor for any immediate adverse reactions. The patient or guardian should be informed about potential side effects and the importance of follow-up doses if applicable.

3. Post-Procedure

Post-procedure care for the Hib-HepB vaccine includes monitoring the patient for any immediate adverse reactions, such as allergic responses or injection site reactions. Patients may experience mild side effects, including soreness at the injection site, low-grade fever, or irritability, which typically resolve within a few days. It is important to provide the patient or guardian with information regarding these potential side effects and to advise them on when to seek medical attention. Additionally, if the vaccine is part of a multi-dose series, the healthcare provider should schedule follow-up appointments to ensure the completion of the vaccination series for optimal immunity.

Short Descr HIB-HEPB VACCINE IM
Medium Descr HIB-HEPB VACCINE FOR INTRAMUSCULAR USE
Long Descr Hepatitis B and Haemophilus influenzae type b vaccine (Hib-HepB), for intramuscular use
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 0
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
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Notes
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2011-01-01 Changed Short description changed.
1998-01-01 Added First appearance in code book in 1998.
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