Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
RedactPHI
HIPAA-Compliant PHI Redaction
DetectICD10CM
ICD-10-CM Code Detection
Log in Register free account
1 code page views remaining. Guest accounts are limited to 1 page view. Register free account to get 5 more views.
Log in Register free account

Official Description

Therapeutic apheresis with selective HDL delipidation and plasma reinfusion

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A therapeutic apheresis procedure is utilized to selectively delipidate high-density lipoprotein (HDL) cholesterol and subsequently reinfuse the treated plasma back into the patient. This advanced medical intervention is particularly relevant for patients experiencing acute coronary syndrome, which may present as unstable angina or non-ST-segment elevation myocardial infarction. The process of apheresis involves the extraction of whole blood from the patient, which is then subjected to a centrifugation technique that separates the blood components. During this procedure, the alpha HDL is transformed into a pre-beta-like HDL, a variant that is more effective in facilitating the removal of lipids from arterial plaque. The conversion to pre-beta-like HDL is significant as it enhances the transport of cholesterol to the liver, thereby contributing to a reduction in atherosclerosis within the blood vessels. This reduction in atherosclerosis is crucial for lowering the risk of developing further cardiovascular complications. The procedure begins with establishing venous access, after which the patient is connected to a specialized machine designed for apheresis. This machine not only separates the blood cells but also incorporates organic solvents to effectively delipidate the HDL. Finally, the modified plasma, now containing the altered HDL, is reinfused back into the patient, completing the therapeutic process.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The therapeutic apheresis with selective HDL delipidation and plasma reinfusion is indicated for specific cardiovascular conditions. The primary indications include:

  • Acute Coronary Syndrome This procedure is performed in patients experiencing acute coronary syndrome, which may manifest as unstable angina or non-ST-segment elevation myocardial infarction.

2. Procedure

The procedure involves several critical steps to ensure effective treatment. Each step is designed to facilitate the safe and efficient delipidation of HDL cholesterol.

  • Step 1: Establishing Venous Access The first step in the procedure is to establish venous access. This is typically done by inserting a catheter into a suitable vein, allowing for the withdrawal of whole blood from the patient. Proper venous access is crucial for the subsequent steps of the apheresis process.
  • Step 2: Blood Withdrawal Once venous access is secured, the patient is connected to an apheresis machine. The machine begins the process by withdrawing whole blood from the patient. This blood will be processed to separate its components.
  • Step 3: Centrifugation The withdrawn blood is then subjected to a centrifugation process within the apheresis machine. This step is essential as it separates the blood cells from the plasma, allowing for the isolation of HDL cholesterol.
  • Step 4: Delipidation of HDL After the separation, the isolated plasma is treated with organic solvents inside the machine. This treatment specifically targets the alpha HDL, converting it into pre-beta-like HDL. This transformation is critical as pre-beta-like HDL is more effective in lipid removal from arterial plaque.
  • Step 5: Plasma Reinjection Finally, the modified plasma, now containing the altered HDL, is reinfused back into the patient. This step completes the therapeutic apheresis process, aiming to enhance cholesterol transport to the liver and reduce atherosclerosis risk.

3. Post-Procedure

Post-procedure care involves monitoring the patient for any immediate adverse reactions to the apheresis process. Patients may be observed for changes in vital signs and any signs of complications related to venous access or the reinfusion of plasma. It is also important to assess the patient's overall response to the treatment, including any improvements in symptoms related to acute coronary syndrome. Follow-up appointments may be scheduled to evaluate the long-term effectiveness of the procedure and to monitor lipid levels and cardiovascular health.

Short Descr THXP APHERESIS W/HDL DELIP
Medium Descr THERAPEUTIC APHERESIS W/SELECTIVE HDL DELIP
Long Descr Therapeutic apheresis with selective HDL delipidation and plasma reinfusion
Status Code Carriers Price the Code
Global Days YYY - Carrier Determines Whether Global Concept Applies
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Berenson-Eggers TOS (BETOS) T2D - Other tests - other
MUE 1
Date
Action
Notes
2015-01-01 Added First appearance in code book
2014-01-01 Added Added
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"