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Official Description

Transcatheter intracoronary infusion of supersaturated oxygen in conjunction with percutaneous coronary revascularization during acute myocardial infarction, including catheter placement, imaging guidance (eg, fluoroscopy), angiography, and radiologic supervision and interpretation

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 0659T refers to a specialized medical procedure known as transcatheter intracoronary infusion of supersaturated oxygen (SSO2) in conjunction with percutaneous coronary revascularization during an acute myocardial infarction (AMI). This procedure is designed to deliver hyperbaric levels of oxygen directly to damaged heart tissue, specifically targeting the ischemic areas of the heart that are affected during a heart attack. The infusion of SSO2 is particularly indicated for patients experiencing a left anterior descending ST-elevation myocardial infarction (LAD STEMI), which is recognized as one of the most critical types of heart attacks due to its potential to cause significant damage to the heart muscle. The SSO2 therapy is administered through a catheter-based approach, allowing for a direct infusion of oxygenated saline solution mixed with the patient’s own blood into the coronary arteries. This method aims to reduce the size of the infarct by restoring capillary blood flow and preventing further tissue necrosis. The procedure is typically performed in a catheterization laboratory (cath lab) shortly after the successful revascularization of the LAD artery, which is achieved through angioplasty and stenting. The SSO2 system comprises a mobile console and a disposable cartridge that generates the superoxygenated solution, ensuring that the delivery is both efficient and effective during the critical window following an acute myocardial infarction.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The transcatheter intracoronary infusion of supersaturated oxygen (CPT® Code 0659T) is indicated for the following conditions:

  • Left Anterior Descending ST-Elevation Myocardial Infarction (LAD STEMI) This procedure is specifically indicated for patients experiencing a LAD STEMI, which is the most severe form of heart attack, characterized by a significant blockage in the left anterior descending artery that can lead to extensive damage to the heart muscle.

2. Procedure

The procedure for transcatheter intracoronary infusion of supersaturated oxygen involves several critical steps to ensure effective delivery of the therapy:

  • Preparation of the SSO2 System The SSO2 system is set up in the catheterization laboratory while the patient is undergoing percutaneous coronary intervention (PCI) to revascularize the LAD artery. This setup includes a mobile console and a disposable cartridge that creates a superoxygenated saline solution. The system continuously mixes this solution with a small amount of the patient’s own blood.
  • Access Site Establishment The procedure can utilize various access site approaches, including a coaxial femoral access site for blood draw and delivery, dual femoral artery access using the contralateral side, or a combination of femoral artery access for blood draw and radial artery access for delivery. The appropriate introducer sheaths are placed to facilitate these access points.
  • Guidewire Positioning A guidewire is positioned through the introducer sheaths to navigate to the left main coronary artery (LMCA). This step is performed under fluoroscopic guidance to ensure accurate placement.
  • SSO2 Delivery Catheter Insertion The SSO2 delivery catheter is threaded over the guidewire and advanced to the LMCA. This catheter is specifically designed to deliver the supersaturated oxygen solution directly to the ischemic cardiac muscle.
  • Infusion of SSO2 After successful angioplasty and stenting of the LAD artery, the SSO2 delivery catheter is utilized to administer a one-time infusion of supersaturated oxygen to the LMCA. This infusion lasts for 60 minutes, during which it aims to restore capillary blood flow and halt tissue necrosis in the affected areas of the heart.

3. Post-Procedure

Following the transcatheter intracoronary infusion of supersaturated oxygen, patients are typically monitored for any immediate complications related to the procedure. Continuous assessment of cardiac function and vital signs is essential to ensure that the infusion has effectively restored blood flow and that there are no adverse reactions. The expected recovery period may vary based on individual patient factors and the extent of the myocardial infarction. Additional follow-up care may include cardiac rehabilitation and ongoing monitoring of heart health to prevent future cardiac events.

Short Descr TCAT INTRA-C NFS SUPERSAT O2
Medium Descr TCAT INTRA-C NFS SUPERSAT O2 W/PERQ C REVSC AMI
Long Descr Transcatheter intracoronary infusion of supersaturated oxygen in conjunction with percutaneous coronary revascularization during acute myocardial infarction, including catheter placement, imaging guidance (eg, fluoroscopy), angiography, and radiologic supervision and interpretation
Status Code Carriers Price the Code
Global Days YYY - Carrier Determines Whether Global Concept Applies
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Inpatient Procedures, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE 1
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2022-01-01 Added First appearance in codebook.
2021-07-01 Added Code added.
Code
Description
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