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Official Description

Absolute quantitation of myocardial blood flow (AQMBF), single-photon emission computed tomography (SPECT), with exercise or pharmacologic stress, and at rest, when performed (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Absolute quantitation of myocardial blood flow (AQMBF) is a diagnostic procedure that utilizes single-photon emission computed tomography (SPECT) to assess blood flow to the heart muscle. This technique is particularly valuable in diagnosing and monitoring coronary artery disease, as well as evaluating the severity of microvascular disease and the effectiveness of treatment interventions. The procedure begins with the establishment of intravenous access, followed by the placement of electrocardiogram (ECG) leads and a blood pressure cuff on the patient's arm. The patient is positioned flat on a table in the procedure room, where myocardial perfusion imaging is conducted either at rest or under stress. Stress can be induced through physical exercise, such as walking on a treadmill or pedaling on a stationary bike, or through the administration of a pharmacologic agent via intravenous injection. During the procedure, a radionuclide tracer is injected, which allows for the imaging of the myocardium. Healthy heart tissue absorbs the radionuclide, while ischemic areas do not, providing critical information about blood flow. The imaging data is processed using dedicated software, which analyzes the images and generates a polar map that illustrates the relative perfusion of the coronary arterial beds and myocardial tissue. The output includes numerical data reflecting blood flow in milliliters per gram per minute (mL/g/min) at both rest and stress conditions. This AQMBF data is then integrated with static perfusion imaging results to create a comprehensive report. It is important to note that CPT® Code 0742T is reported separately in addition to the code for the primary SPECT procedure, highlighting its role as an adjunctive measure in the overall assessment of myocardial perfusion.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The absolute quantitation of myocardial blood flow (AQMBF) using single-photon emission computed tomography (SPECT) is indicated for the following conditions:

  • Coronary Artery Disease - To diagnose and monitor the presence and severity of coronary artery disease.
  • Microvascular Disease - To evaluate the severity of microvascular disease, which can affect blood flow in the smaller coronary vessels.
  • Treatment Response - To assess the response to therapeutic interventions aimed at improving myocardial perfusion.

2. Procedure

The procedure for absolute quantitation of myocardial blood flow (AQMBF) involves several key steps that ensure accurate imaging and assessment of myocardial perfusion:

  • Step 1: Establishing Access - An intravenous access line is established to facilitate the administration of the radionuclide tracer and any pharmacologic agents required for stress testing.
  • Step 2: Patient Preparation - Electrocardiogram (ECG) leads are placed on the patient to monitor heart activity throughout the procedure. A blood pressure cuff is also applied to the arm to measure blood pressure during the test.
  • Step 3: Positioning the Patient - The patient is positioned flat on a table in the procedure room, ensuring comfort and stability during the imaging process.
  • Step 4: Inducing Stress - Myocardial perfusion imaging is performed either at rest or under stress. Stress can be induced through physical exercise, such as using a treadmill or stationary bike, or through the intravenous injection of a pharmacologic agent that simulates the effects of exercise on the heart.
  • Step 5: Administering the Radionuclide Tracer - A radionuclide tracer is injected into the patient’s bloodstream. This tracer is crucial for visualizing blood flow to the heart muscle during imaging.
  • Step 6: Imaging - Images of the myocardium are obtained at rest and during cardiac stress. The radionuclide localizes in healthy heart tissue, while ischemic areas do not absorb the tracer, allowing for differentiation between normal and compromised blood flow.
  • Step 7: Data Processing and Analysis - The imaging data is processed using dedicated software that analyzes the captured images. This software generates a polar map that represents the relative perfusion of the coronary arterial beds and myocardial tissue.
  • Step 8: Reporting - Numerical output data is provided in milliliters per gram per minute (mL/g/min) for both rest and stress conditions. The AQMBF data is then combined with static perfusion imaging data to create a complete report for clinical evaluation.

3. Post-Procedure

After the procedure, patients may be monitored for a short period to ensure there are no immediate adverse reactions to the radionuclide tracer or the pharmacologic agent used during stress testing. Patients are typically advised to hydrate well to help flush the radionuclide from their system. Follow-up appointments may be scheduled to discuss the results of the AQMBF assessment and any further diagnostic or therapeutic steps that may be necessary based on the findings. It is essential for healthcare providers to review the complete report generated from the AQMBF data in conjunction with other clinical information to make informed decisions regarding patient care.

Short Descr AQMBF SPECT XERS/STRS & REST
Medium Descr AQMBF SPECT W/EXERCISE/RX STRESS & REST
Long Descr Absolute quantitation of myocardial blood flow (AQMBF), single-photon emission computed tomography (SPECT), with exercise or pharmacologic stress, and at rest, when performed (List separately in addition to code for primary procedure)
Status Code Carriers Price the Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) none
MUE 1

This is an add-on code that must be used in conjunction with one of these primary codes.

78451 MPFS Status: Active Code APC S ASC Z2 CPT Assistant Article Illustration for Code Myocardial perfusion imaging, tomographic (SPECT) (including attenuation correction, qualitative or quantitative wall motion, ejection fraction by first pass or gated technique, additional quantification, when performed); single study, at rest or stress (exercise or pharmacologic)
78452 MPFS Status: Active Code APC S ASC Z2 CPT Assistant Article Illustration for Code Myocardial perfusion imaging, tomographic (SPECT) (including attenuation correction, qualitative or quantitative wall motion, ejection fraction by first pass or gated technique, additional quantification, when performed); multiple studies, at rest and/or stress (exercise or pharmacologic) and/or redistribution and/or rest reinjection
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
Date
Action
Notes
2023-01-01 Added Code added.
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