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Official Description

Clotting; factor VIII (AHG), 1-stage

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Clotting factor VIII is a crucial protein in the blood coagulation process, and its deficiency leads to hemophilia A, which is the most prevalent form of hemophilia. This inherited disorder is characterized by a significant reduction or absence of factor VIII, which is essential for the formation of stable blood clots. The CPT® Code 85240 specifically refers to a one-stage clotting test that measures the activity of factor VIII in the blood. This test is vital for diagnosing hemophilia A, as well as identifying acquired deficiencies that may arise from conditions such as liver disease or disseminated intravascular coagulopathy (DIC). During the testing process, a blood sample is collected from the patient, and the factor VIII activity is assessed by performing a one-stage clotting test. This involves comparing various dilutions of the patient's blood sample against a standardized set of dilutions to determine the level of factor VIII activity. The results of this test are typically expressed as a percentage, providing a clear indication of the patient's clotting ability related to factor VIII levels.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The one-stage clotting test for factor VIII activity, represented by CPT® Code 85240, is indicated for the following conditions:

  • Hemophilia A - This test is primarily performed to diagnose hemophilia A, which is characterized by a deficiency of factor VIII.
  • Acquired factor VIII deficiency - The test can also be used to identify acquired deficiencies that may occur due to liver disease or disseminated intravascular coagulopathy (DIC).

2. Procedure

The procedure for conducting the one-stage clotting test for factor VIII activity involves several key steps:

  • Step 1: Blood Sample Collection - A blood sample is obtained from the patient, typically through venipuncture. This sample serves as the basis for the subsequent testing of factor VIII activity.
  • Step 2: Sample Preparation - The collected blood sample is processed to separate the plasma, which is necessary for the one-stage clotting test. This may involve centrifugation to ensure that the plasma is isolated from the cellular components of the blood.
  • Step 3: Performing the One-Stage Clotting Test - The one-stage clotting test is conducted by mixing the prepared plasma sample with a series of dilutions. These dilutions are compared against a known set of standard dilutions to evaluate the factor VIII activity. The test measures the time it takes for the blood to clot in the presence of the factor VIII, allowing for an assessment of the patient's clotting ability.
  • Step 4: Result Interpretation - The results of the test are expressed as a percentage, indicating the level of factor VIII activity in the patient's blood. This percentage is then compared to normal reference ranges to determine if a deficiency is present.

3. Post-Procedure

After the one-stage clotting test is completed, the patient may be monitored for any immediate reactions to the blood draw, although significant post-procedure care is generally not required. The results will be analyzed by a healthcare professional, who will interpret the factor VIII activity percentage in the context of the patient's clinical history and symptoms. If a deficiency is identified, further evaluation and management may be necessary, which could include additional testing or treatment options tailored to the patient's specific condition.

Short Descr CLOT FACTOR VIII AHG 1 STAGE
Medium Descr CLOTTING FACTOR VIII AHG 1 STAGE
Long Descr Clotting; factor VIII (AHG), 1-stage
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
GA Waiver of liability statement issued as required by payer policy, individual case
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
Q4 Service for ordering/referring physician qualifies as a service exemption
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
2010-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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Description
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