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Official Description

Clotting; factor X (Stuart-Prower)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 85260 refers to a laboratory test specifically designed to measure the activity of clotting factor X, also known as Stuart-Prower factor. This factor is a crucial component in the coagulation cascade, which is the series of events that lead to blood clot formation. Factor X is classified as a vitamin K dependent serine protease, meaning that its activity is reliant on the presence of vitamin K, which is essential for the synthesis of several clotting factors in the liver. The activation of factor X is a pivotal step in the clotting process, as it leads to the conversion of prothrombin to thrombin, ultimately resulting in the formation of a fibrin clot. A deficiency in factor X is considered rare and can arise from various causes, including inherited genetic disorders, vitamin K deficiency, systemic amyloidosis, severe liver disease, or the effects of anticoagulant therapy. Clinically, individuals with factor X deficiency may present with symptoms such as easy bruising, frequent nosebleeds, hematuria (blood in urine), heavy menstrual bleeding, and bleeding into soft tissues or joints. The test for factor X activity is often ordered to diagnose either congenital or acquired factor X deficiency, to investigate the underlying causes of abnormal bleeding time tests such as prothrombin time (PT) and activated partial thromboplastin time (PTT), or to evaluate the impact of liver disease on the body's hemostatic mechanisms. The test is performed by obtaining a blood sample through venipuncture, which is reported separately, and the analysis is conducted on platelet-poor plasma using a prothrombin clot-based assay to accurately measure the activity of factor X.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 85260 is indicated for use in various clinical scenarios where the assessment of clotting factor X activity is necessary. The following conditions may warrant the ordering of this test:

  • Diagnosis of Factor X Deficiency This test is utilized to diagnose both congenital and acquired deficiencies of factor X, which can lead to abnormal bleeding tendencies.
  • Investigation of Abnormal Bleeding Time Tests The test may be ordered to further investigate abnormal results from bleeding time tests, such as prothrombin time (PT) and activated partial thromboplastin time (PTT), which can indicate underlying coagulation disorders.
  • Assessment of Liver Disease Impact on Hemostasis It is also used to evaluate how liver disease affects hemostatic function, as the liver plays a critical role in the synthesis of clotting factors, including factor X.

2. Procedure

The procedure for performing the test associated with CPT® Code 85260 involves several key steps that ensure accurate measurement of factor X activity. The following outlines the procedural steps:

  • Step 1: Blood Sample Collection A blood sample is obtained from the patient through a venipuncture, which is a standard procedure for drawing blood. This step is crucial as it provides the necessary specimen for testing. The blood collected must be handled carefully to prevent contamination and ensure the integrity of the sample.
  • Step 2: Preparation of Platelet-Poor Plasma After collection, the blood sample is processed to obtain platelet-poor plasma. This is typically achieved by centrifuging the blood sample, which separates the plasma from the cellular components, including platelets. The removal of platelets is essential as they can interfere with the clotting assays.
  • Step 3: Prothrombin Clot-Based Assay The prepared platelet-poor plasma is then subjected to a prothrombin clot-based assay. This assay measures the activity of factor X by evaluating the time it takes for a clot to form in the presence of specific reagents that activate the clotting cascade. The results of this assay provide a quantitative measure of factor X activity, which is critical for diagnosing deficiencies.

3. Post-Procedure

Post-procedure care for the patient following the blood draw is generally minimal. Patients may be advised to apply pressure to the venipuncture site to minimize bruising and bleeding. It is also important to monitor for any signs of complications, such as excessive bleeding or infection at the site. The results of the factor X activity test will typically be available within a specified timeframe, allowing healthcare providers to make informed decisions regarding diagnosis and treatment based on the findings. Additionally, any abnormal results may necessitate further testing or evaluation to determine the underlying cause of the deficiency or bleeding disorder.

Short Descr CLOT FACTOR X STUART-POWER
Medium Descr CLOTTING FACTOR X STUART-PROWER
Long Descr Clotting; factor X (Stuart-Prower)
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
GA Waiver of liability statement issued as required by payer policy, individual case
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
Pre-1990 Added Code added.
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Description
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Description
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