CPT® Code 85244

1. Indications

The factor VIII related antigen test (CPT® Code 85244) is indicated for several specific clinical scenarios, particularly in the context of bleeding disorders. The following conditions may warrant the performance of this test:

• Assessment of Hemophilia A This test is crucial for diagnosing and managing Hemophilia A, a genetic disorder characterized by a deficiency in factor VIII, leading to impaired blood clotting.
• Evaluation of Factor VIII Replacement Therapy The test is used to monitor the effectiveness of factor VIII replacement therapy in patients with hemophilia, ensuring that adequate levels of the protein are maintained to prevent bleeding episodes.
• Determination of Carrier Status The test can help identify individuals who are carriers of the hemophilia gene, particularly in families with a history of the disorder, aiding in genetic counseling and family planning.
• Identification of Cross-Reactive Positivity (CRP) The test may be utilized to distinguish patients who may exhibit cross-reactive positivity, which can impact treatment decisions and management strategies.

2. Procedure

The procedure for conducting the factor VIII related antigen test involves several key steps that ensure accurate measurement of the antigen levels in the blood. The following outlines the procedural steps:

• Step 1: Patient Preparation Prior to the test, the patient may be instructed to avoid certain medications or supplements that could interfere with the results. It is essential to gather a thorough medical history to understand any potential factors that may affect the test outcome.
• Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to draw a sufficient volume of blood for testing. The venipuncture procedure is separately reportable and must be documented appropriately.
• Step 3: Sample Handling Once the blood sample is collected, it must be handled and processed according to laboratory protocols. This includes labeling the sample accurately and ensuring it is transported to the laboratory under the correct conditions to maintain sample integrity.
• Step 4: Immunoassay Testing The laboratory performs the analysis using immunoassay techniques, which are designed to quantify the level of factor VIII related antigen present in the blood sample. This method provides reliable and precise results that are essential for clinical decision-making.
• Step 5: Result Interpretation After the testing is complete, the results are interpreted by a qualified healthcare professional. The findings will inform the management of the patient’s condition, including any necessary adjustments to treatment plans.

3. Post-Procedure

After the factor VIII related antigen test is completed, patients may be advised on post-procedure care, although specific instructions may vary based on individual circumstances. Generally, patients can resume normal activities immediately following the venipuncture, but they should be monitored for any signs of excessive bleeding or bruising at the puncture site. If any adverse reactions occur, such as prolonged bleeding or discomfort, patients should contact their healthcare provider for further evaluation. Additionally, the results of the test will typically be discussed with the patient during a follow-up appointment, where the implications for treatment and management of their condition will be addressed.