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Official Description

Influenza virus vaccine, quadrivalent (RIV4), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90682 refers to the quadrivalent influenza virus vaccine, specifically the recombinant influenza vaccine (RIV4). This vaccine is unique as it is produced without the use of the live influenza virus or eggs, making it suitable for individuals with egg allergies. The production process utilizes an insect virus known as baculovirus, combined with recombinant DNA technology, to generate the hemagglutinin (HA) protein, which is a key component of the influenza virus. This innovative method allows for a more rapid response in vaccine production, particularly beneficial during pandemic situations when swift immunization is critical. The quadrivalent formulation of this vaccine includes four full-strength recombinant HA proteins, providing protection against two strains of Influenza A and two strains of Influenza B. The vaccine is administered via intramuscular injection, and it is important to note that the administration of this vaccine is reported separately in medical billing and coding practices.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The quadrivalent influenza virus vaccine (CPT® Code 90682) is indicated for the prevention of influenza caused by specific strains of the virus. The following conditions and situations warrant the administration of this vaccine:

  • Seasonal Influenza Prevention This vaccine is recommended for individuals seeking protection against seasonal influenza, particularly during flu season when the virus is prevalent.
  • High-Risk Populations It is especially indicated for high-risk groups, including the elderly, young children, pregnant women, and individuals with chronic health conditions that may increase the risk of influenza complications.
  • Individuals with Egg Allergies The vaccine is suitable for those who have a history of egg allergies, as it is produced without the use of eggs or egg-derived components.

2. Procedure

The administration of the quadrivalent influenza virus vaccine involves several key procedural steps, which are outlined as follows:

  • Step 1: Patient Assessment Prior to vaccination, a thorough assessment of the patient’s medical history is conducted to identify any contraindications or allergies, particularly to eggs or vaccine components.
  • Step 2: Preparation of the Vaccine The vaccine is prepared according to the manufacturer's guidelines, ensuring that it is stored at the appropriate temperature and is within its expiration date. The vial is inspected for any particulate matter or discoloration before use.
  • Step 3: Administration of the Vaccine The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for adults and older children, or in the anterolateral thigh for infants and young children. The injection site is cleaned with an antiseptic wipe prior to administration.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions, such as allergic responses. This monitoring typically lasts for 15 minutes.

3. Post-Procedure

Following the administration of the quadrivalent influenza virus vaccine, patients may experience mild side effects, which can include soreness at the injection site, low-grade fever, or fatigue. These symptoms are generally self-limiting and resolve within a few days. Patients are advised to rest and stay hydrated. It is also important to inform patients about the signs of a severe allergic reaction, such as difficulty breathing or swelling of the face and throat, and to seek immediate medical attention if these occur. Additionally, patients should be encouraged to receive the vaccine annually, as influenza virus strains can change from year to year, necessitating updated immunization for optimal protection.

Short Descr RIV4 VACC RECOMBINANT DNA IM
Medium Descr RIV4 VACC RECOMBINANT DNA PRSRV ANTIBIO FREE IM
Long Descr Influenza virus vaccine, quadrivalent (RIV4), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use
Related Drugs Flublok Quadrivalent Northern Hemisphere
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) none
MUE 1
JZ Zero drug amount discarded/not administered to any patient
GW Service not related to the hospice patient's terminal condition
GA Waiver of liability statement issued as required by payer policy, individual case
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
GC This service has been performed in part by a resident under the direction of a teaching physician
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
SL State supplied vaccine
Date
Action
Notes
2018-01-01 Added First appearance in code book.
2017-01-01 Added Code added.
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Description
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Description
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