Coding Ahead
CasePilot
Medical Coding Assistant
Case2Code
Search and Code Lookup Tool
RedactPHI
HIPAA-Compliant PHI Redaction
DetectICD10CM
ICD-10-CM Code Detection
Log in Register free account
1 code page views remaining. Guest accounts are limited to 1 page view. Register free account to get 5 more views.
Log in Register free account

Official Description

Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, 0.25 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A quadrivalent influenza virus vaccine, specifically identified by CPT® Code 90685, is a split virus formulation that is preservative-free and intended for intramuscular administration. This vaccine is designed to provide active, long-term immunity against influenza by introducing altered versions of the virus into the recipient's immune system. Unlike immune globulins, which offer short-term, passive immunity, vaccines stimulate the immune system to produce its own antibodies, enabling the body to recognize and combat the virus upon future exposure. The preservative-free aspect of this vaccine indicates that it does not contain the preservative thimerosal, or contains only trace amounts, and is classified as either thimerosal-free or thimerosal-reduced, both of which are recognized by the FDA as preservative-free. The vaccine is prepared using embryonated chicken eggs, where the virus is harvested, inactivated with formaldehyde, concentrated, purified, and chemically disrupted to create a split virus. This specific formulation protects against four strains of influenza viruses, including two type A strains and two type B strains. For accurate reporting, CPT® Code 90685 is used for a 0.25 mL dosage of the vaccine administered intramuscularly, while CPT® Code 90686 is designated for a 0.5 mL dosage. It is important to note that these codes solely represent the vaccine product and that the intramuscular injection itself should be reported separately.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The quadrivalent influenza virus vaccine (IIV4) is indicated for the prevention of influenza caused by the four specific strains of the virus included in the vaccine formulation. The vaccine is recommended for individuals who are at risk of contracting influenza, particularly during the influenza season. The following conditions and populations may warrant vaccination:

  • High-Risk Populations Individuals with chronic health conditions, such as asthma, diabetes, or heart disease, who are more susceptible to severe influenza complications.
  • Healthcare Workers Those who work in healthcare settings and are at increased risk of exposure to influenza viruses.
  • Pregnant Women Pregnant individuals, as they are at higher risk for severe illness from influenza.
  • Children and Elderly Young children and older adults, who are more vulnerable to influenza-related complications.

2. Procedure

The administration of the quadrivalent influenza virus vaccine involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine:

  • Step 1: Preparation Prior to administration, the vaccine should be thoroughly inspected for any particulate matter or discoloration. The vaccine vial should be shaken gently to ensure proper mixing of the contents.
  • Step 2: Site Selection The healthcare provider should select an appropriate site for intramuscular injection, typically the deltoid muscle of the upper arm for adults and older children, or the anterolateral thigh for infants and young children.
  • Step 3: Injection Technique The provider should clean the injection site with an alcohol swab and allow it to dry. Using a sterile syringe and needle, the provider will insert the needle at a 90-degree angle to the skin and inject the 0.25 mL dosage of the vaccine into the muscle. The needle should be withdrawn quickly and a cotton ball or gauze should be applied to the site to minimize bleeding.
  • Step 4: Post-Administration Care After the injection, the patient should be monitored for a short period to observe for any immediate adverse reactions. The provider should provide the patient with information regarding potential side effects and the importance of reporting any unusual symptoms.

3. Post-Procedure

Following the administration of the quadrivalent influenza virus vaccine, patients are typically advised to remain in the healthcare setting for a brief observation period to monitor for any immediate allergic reactions or side effects. Common post-vaccination reactions may include soreness at the injection site, mild fever, or fatigue, which usually resolve within a few days. Patients should be informed about the importance of reporting any severe or unusual reactions to their healthcare provider. Additionally, it is essential to remind patients that the vaccine does not provide immediate immunity and that it may take up to two weeks for the body to develop protective antibodies against the influenza virus. Regular follow-up and vaccination during the influenza season are recommended to maintain immunity.

Short Descr IIV4 VACC NO PRSV 0.25 ML IM
Medium Descr IIV4 VACC PRSRV FREE 0.25 ML DOS FOR IM USE
Long Descr Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, 0.25 mL dosage, for intramuscular use
Related Drugs Afluria Quadrivalent
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
Date
Action
Notes
2017-01-01 Changed Long, Medium and Short descriptions changed.
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2014-01-01 Added First appearance in codebook.
2013-06-07 Changed Approved by FDA. Removed the 'Product Pending FDA Approval' flag.
2013-01-01 Added Coded added
Code
Description
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"