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Code deleted, see 15275-15278

Official Description

Xenograft skin (dermal), for temporary wound closure, face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; first 100 sq cm or less, or 1% of body area of infants and children

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Common Language Description

A dermal xenograft is a specialized type of skin graft used for temporary wound closure in various anatomical locations, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This procedure involves the application of skin or tissue obtained from another species, most commonly porcine (pig) skin, which is referred to as a heterograft. The porcine grafts undergo a treatment process involving glycerol and are either frozen using liquid nitrogen or freeze-dried, a method known as lyophilization. The primary purpose of a xenograft is to serve as a biologic dressing that provides a protective barrier over the wound until it is eventually rejected by the patient's immune system. When preparing for the application of a xenograft, the graft is thawed if it has been frozen or rehydrated if it has been lyophilized. The graft is then carefully placed onto the prepared wound bed and secured in position using sutures. The CPT® Code 15420 is specifically designated for the use of a dermal xenograft for the first 100 square centimeters or less in adults, or for 1% of the total body surface area (TBSA) in infants and children. For cases requiring additional coverage beyond this initial area, CPT® Code 15421 should be utilized for each subsequent 100 square centimeters in adults or 1% of TBSA in infants and children, or any part thereof.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure involving the application of a dermal xenograft is indicated for temporary wound closure in specific anatomical areas. The following conditions or situations may warrant the use of this procedure:

  • Facial Wounds Wounds located on the face that require temporary closure to promote healing and protect underlying structures.
  • Scalp Injuries Injuries to the scalp that necessitate a biologic dressing to facilitate recovery.
  • Eyelid and Orbital Wounds Wounds affecting the eyelids or surrounding orbital area that require careful management to maintain function and appearance.
  • Mouth and Neck Injuries Traumatic or surgical wounds in the mouth or neck region that need temporary coverage.
  • Genitalia and Extremity Wounds Wounds on the genitalia, hands, feet, or multiple digits that require a protective graft for healing.

2. Procedure

The procedure for applying a dermal xenograft involves several critical steps to ensure proper placement and effectiveness. Each step is outlined as follows:

  • Preparation of the Wound Bed The first step involves preparing the wound bed to ensure it is clean and free of debris. This may include debridement of necrotic tissue and thorough cleansing to promote optimal graft adherence.
  • Thawing or Rehydrating the Graft If the xenograft has been frozen, it must be thawed using appropriate methods to ensure it is ready for application. Alternatively, if the graft has been lyophilized, it should be rehydrated to restore its pliability and functionality.
  • Application of the Graft Once the graft is prepared, it is carefully placed onto the wound bed. The surgeon must ensure that the graft adequately covers the wound area, providing a protective barrier.
  • Securing the Graft After placement, the xenograft is secured in position using sutures. This step is crucial to maintain the graft's position and facilitate integration with the surrounding tissue.

3. Post-Procedure

Post-procedure care is essential to ensure the success of the xenograft application. Patients should be monitored for signs of graft rejection, which may include changes in color, texture, or the presence of exudate. It is important to keep the graft site clean and dry, and patients may be advised to avoid activities that could disrupt the graft. Follow-up appointments are necessary to assess the healing process and determine if further interventions are required. The expected recovery time may vary depending on the individual and the extent of the wound, but the xenograft typically serves as a temporary solution until the patient's own skin can heal adequately.

Short Descr APPLY SKIN XGRAFT F/N/HF/G
Medium Descr XENOGRF TEMP CLOSURE F/S/N/H/F/G/M/D 1ST 100CM
Long Descr XENOGRF TEMP CLOSURE F/S/N/H/F/G/M/D 1ST 100CM
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Discontinued Code
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
CCS Clinical Classification 172 - Skin graft
Date
Action
Notes
2012-01-01 Deleted Code deleted, see 15275-15278
2011-01-01 Changed Short description changed.
2007-01-01 Changed Code description changed.
2006-01-01 Added Code added.
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Description
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