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Official Description

Esophagogastroduodenoscopy, flexible, transoral; with transendoscopic ultrasound-guided intramural or transmural fine needle aspiration/biopsy(s), (includes endoscopic ultrasound examination limited to the esophagus, stomach or duodenum, and adjacent structures)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

An esophagogastroduodenoscopy (EGD) is a specialized upper gastrointestinal (UGI) endoscopic examination that allows for the visualization and assessment of the esophagus, stomach, and duodenum. This procedure is performed using a flexible fiberoptic endoscope, which is a thin, flexible tube equipped with a light and camera. The procedure begins with the administration of a local anesthetic spray to numb the mouth and throat, facilitating the insertion of the endoscope. A hollow mouthpiece is placed in the patient's mouth to keep it open during the examination. As the patient swallows, the endoscope is carefully advanced through the esophagus, allowing for direct visualization of the esophageal lining and any potential abnormalities. Once the endoscope is positioned beyond the cricopharyngeal region, the examination continues with the inspection of the esophagus, followed by the advancement of the endoscope into the stomach. The stomach is insufflated with air to enhance visibility, and various regions, including the cardia, fundus, greater and lesser curvature, and antrum, are thoroughly examined for abnormalities. The endoscope is then advanced through the pylorus into the duodenum and/or jejunum, where the mucosal surfaces are inspected for any signs of lesions, ulcerations, varices, or other abnormalities. In addition to the visual examination, this procedure includes an endoscopic ultrasound (EUS) component, which provides detailed imaging of the esophageal wall as a five-layer structure. This imaging capability allows for a more comprehensive assessment of the esophagus and surrounding structures. If necessary, the procedure may also involve transendoscopic ultrasound-guided fine needle aspiration or biopsy. This technique allows for the collection of tissue samples from the esophageal wall or surrounding structures, such as lymph nodes, to aid in diagnosis and treatment planning. Overall, CPT® Code 43238 encompasses both the endoscopic examination and the advanced diagnostic capabilities provided by EUS and fine needle aspiration/biopsy.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The esophagogastroduodenoscopy with transendoscopic ultrasound-guided fine needle aspiration/biopsy is indicated for various clinical scenarios where detailed examination and tissue sampling of the upper gastrointestinal tract are necessary. The following conditions may warrant this procedure:

  • Suspicion of Malignancy - When there is a clinical suspicion of cancer in the esophagus, stomach, or duodenum, this procedure allows for direct visualization and biopsy of suspicious lesions.
  • Unexplained Gastrointestinal Symptoms - Patients presenting with unexplained symptoms such as dysphagia (difficulty swallowing), weight loss, or gastrointestinal bleeding may require this procedure for diagnosis.
  • Assessment of Abnormal Imaging Findings - If imaging studies (e.g., CT scans) reveal abnormalities in the upper gastrointestinal tract, an EGD with EUS can provide further evaluation and tissue sampling.
  • Evaluation of Lymphadenopathy - Enlarged lymph nodes adjacent to the esophagus or stomach may necessitate biopsy to determine the cause of the enlargement.

2. Procedure

The procedure involves several key steps to ensure a thorough examination and accurate tissue sampling:

  • Preparation and Anesthesia - The patient is prepared for the procedure by administering a local anesthetic spray to numb the throat and mouth, facilitating the insertion of the endoscope. A hollow mouthpiece is placed in the mouth to keep it open during the examination.
  • Insertion of the Endoscope - The flexible fiberoptic endoscope is inserted into the mouth and advanced through the esophagus as the patient swallows. The endoscope is guided using direct visualization, allowing for careful navigation through the upper gastrointestinal tract.
  • Inspection of the Esophagus - Once the endoscope is positioned beyond the cricopharyngeal region, the esophagus is thoroughly inspected for any abnormalities, such as lesions or inflammation.
  • Endoscopic Ultrasound Examination - An endoscopic ultrasound (EUS) is performed to obtain detailed images of the esophageal wall, which is visualized as a five-layer structure. This imaging helps assess the depth of any lesions and the involvement of surrounding structures.
  • Advancement into the Stomach - The endoscope is then advanced into the stomach, which is insufflated with air to enhance visibility. The cardia, fundus, greater and lesser curvature, and antrum are inspected for abnormalities.
  • Advancement into the Duodenum - The endoscope is further advanced through the pylorus into the duodenum and/or jejunum, where the mucosal surfaces are inspected for any signs of lesions or other abnormalities.
  • Fine Needle Aspiration/Biopsy - If indicated, a fine needle aspiration device or biopsy tool is advanced into the esophageal wall at the site of any identified lesions. Tissue samples are obtained using EUS guidance. If biopsies from surrounding structures, such as lymph nodes, are required, the needle is passed through the esophageal wall to obtain transmural biopsies.

3. Post-Procedure

After the completion of the esophagogastroduodenoscopy with transendoscopic ultrasound-guided fine needle aspiration/biopsy, patients are typically monitored for a short period to ensure there are no immediate complications. Common post-procedure care includes the following:

  • Recovery Monitoring - Patients are observed for any signs of complications, such as bleeding or perforation, particularly at the biopsy sites.
  • Dietary Restrictions - Patients may be advised to refrain from eating or drinking until the effects of the anesthetic have worn off and swallowing is safe.
  • Follow-Up Instructions - Patients are provided with specific follow-up instructions, including when to resume normal activities and any signs or symptoms that should prompt immediate medical attention.
Short Descr EGD US FINE NEEDLE BX/ASPIR
Medium Descr EGD INTRMURAL US NEEDLE ASPIRATE/BIOPSY ESOPHAGS
Long Descr Esophagogastroduodenoscopy, flexible, transoral; with transendoscopic ultrasound-guided intramural or transmural fine needle aspiration/biopsy(s), (includes endoscopic ultrasound examination limited to the esophagus, stomach or duodenum, and adjacent structures)
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 43235  Esophagogastroduodenoscopy, flexible, transoral; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8B - Endoscopy - upper gastrointestinal
MUE 1
CCS Clinical Classification 70 - Upper gastrointestinal endoscopy, biopsy
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
GC This service has been performed in part by a resident under the direction of a teaching physician
CR Catastrophe/disaster related
SG Ambulatory surgical center (asc) facility service
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
62 Two surgeons: when 2 surgeons work together as primary surgeons performing distinct part(s) of a procedure, each surgeon should report his/her distinct operative work by adding modifier 62 to the procedure code and any associated add-on code(s) for that procedure as long as both surgeons continue to work together as primary surgeons. each surgeon should report the co-surgery once using the same procedure code. if additional procedure(s) (including add-on procedure(s) are performed during the same surgical session, separate code(s) may also be reported with modifier 62 added. note: if a co-surgeon acts as an assistant in the performance of additional procedure(s), other than those reported with the modifier 62, during the same surgical session, those services may be reported using separate procedure code(s) with modifier 80 or modifier 82 added, as appropriate.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CG Policy criteria applied
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
P3 A patient with severe systemic disease
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
PT Colorectal cancer screening test; converted to diagnostic test or other procedure
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QZ Crna service: without medical direction by a physician
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2015-01-01 Changed Code description changed.
2014-01-01 Changed Description Changed
2004-01-01 Added First appearance in code book in 2004.
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