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Official Description

Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multiple

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

An esophagogastroduodenoscopy (EGD), also known as an upper gastrointestinal (UGI) endoscopic examination, is a diagnostic procedure that allows for the visualization of the esophagus, stomach, and the first part of the small intestine (duodenum). This procedure is performed using a flexible fiberoptic endoscope, which is a thin, tube-like instrument equipped with a light and camera. The endoscope is inserted through the mouth and advanced down the throat into the gastrointestinal tract. Prior to the procedure, the patient's mouth and throat are numbed with an anesthetic spray to minimize discomfort. A hollow mouthpiece is placed in the mouth to facilitate the insertion of the endoscope. During the examination, the physician inspects the lining of the esophagus, stomach, and duodenum for any abnormalities such as inflammation, ulcers, or tumors. If any suspicious areas are identified, the physician can obtain single or multiple biopsy samples through the endoscope for further analysis. The procedure is crucial for diagnosing various gastrointestinal conditions and can provide valuable information regarding the health of the upper digestive tract. After the endoscope is withdrawn, a final inspection of the mucosal surfaces is conducted to check for any additional abnormalities, ensuring a comprehensive evaluation of the patient's gastrointestinal health.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The esophagogastroduodenoscopy (EGD) procedure is indicated for a variety of gastrointestinal symptoms and conditions. These include:

  • Persistent abdominal pain that may indicate underlying gastrointestinal issues.
  • Difficulty swallowing (dysphagia) which may suggest esophageal obstructions or other abnormalities.
  • Unexplained weight loss that could be associated with gastrointestinal diseases.
  • Gastroesophageal reflux disease (GERD) symptoms that require further evaluation.
  • Presence of gastrointestinal bleeding which necessitates investigation to identify the source.
  • Abnormal imaging results from X-rays or other imaging studies that warrant direct visualization of the upper GI tract.

2. Procedure

The esophagogastroduodenoscopy procedure involves several key steps to ensure a thorough examination of the upper gastrointestinal tract. The following outlines the procedural steps:

  • Preparation and Anesthesia - The patient is prepared for the procedure by having their mouth and throat numbed with an anesthetic spray. This step is crucial to minimize discomfort during the insertion of the endoscope.
  • Insertion of the Mouthpiece - A hollow mouthpiece is placed in the patient's mouth to help keep it open and facilitate the passage of the endoscope.
  • Advancement of the Endoscope - The flexible fiberoptic endoscope is carefully inserted through the mouth and advanced down the throat. The patient is instructed to swallow, which aids in the smooth passage of the endoscope beyond the cricopharyngeal region.
  • Inspection of the Esophagus - Once the endoscope is positioned in the esophagus, the physician inspects the lining for any abnormalities, such as inflammation or lesions.
  • Advancement into the Stomach - The endoscope is then advanced through the gastroesophageal junction into the stomach. Air is insufflated to expand the stomach for better visualization. The physician inspects various regions of the stomach, including the cardia, fundus, greater and lesser curvature, and antrum, noting any abnormalities.
  • Inspection of the Duodenum and/or Jejunum - The tip of the endoscope is advanced through the pylorus into the duodenum and/or jejunum. The mucosal surfaces are carefully inspected for any abnormalities, such as ulcers or tumors.
  • Biopsy Collection - If any suspicious tissue is identified during the examination, single or multiple biopsy samples are taken through the endoscope for histological analysis.
  • Withdrawal of the Endoscope - After the examination and biopsy collection, the endoscope is withdrawn. A final inspection of the mucosal surfaces is performed to check for any ulcerations, varices, bleeding sites, lesions, strictures, or other abnormalities.

3. Post-Procedure

After the esophagogastroduodenoscopy procedure, patients are typically monitored for a short period to ensure that they recover from the effects of the anesthetic. It is common for patients to experience a sore throat or mild discomfort following the procedure, which usually resolves quickly. Patients may be advised to refrain from eating or drinking until the effects of the anesthesia have worn off and swallowing is comfortable. Additionally, the physician will provide instructions regarding any necessary follow-up appointments to discuss biopsy results and further management based on the findings of the procedure.

Short Descr EGD BIOPSY SINGLE/MULTIPLE
Medium Descr EGD TRANSORAL BIOPSY SINGLE/MULTIPLE
Long Descr Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multiple
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 43235  Esophagogastroduodenoscopy, flexible, transoral; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8B - Endoscopy - upper gastrointestinal
MUE 1
CCS Clinical Classification 70 - Upper gastrointestinal endoscopy, biopsy
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
SG Ambulatory surgical center (asc) facility service
GC This service has been performed in part by a resident under the direction of a teaching physician
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
GA Waiver of liability statement issued as required by payer policy, individual case
CR Catastrophe/disaster related
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AG Primary physician
PT Colorectal cancer screening test; converted to diagnostic test or other procedure
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
GW Service not related to the hospice patient's terminal condition
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
74 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure after administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may terminate a surgical or diagnostic procedure after the administration of anesthesia (local, regional block(s), general) or after the procedure was started (incision made, intubation started, scope inserted, etc). under these circumstances, the procedure started but terminated can be reported by its usual procedure number and the addition of modifier 74. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
GZ Item or service expected to be denied as not reasonable and necessary
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
47 Anesthesia by surgeon: regional or general anesthesia provided by the surgeon may be reported by adding modifier 47 to the basic service. (this does not include local anesthesia.) note: modifier 47 would not be used as a modifier for the anesthesia procedures.
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
56 Preoperative management only: when 1 physician or other qualified health care professional performed the preoperative care and evaluation and another performed the surgical procedure, the preoperative component may be identified by adding modifier 56 to the usual procedure number.
73 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure prior to the administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may cancel a surgical or diagnostic procedure subsequent to the patient's surgical preparation (including sedation when provided, and being taken to the room where the procedure is to be performed), but prior to the administration of anesthesia (local, regional block(s) or general). under these circumstances, the intended service that is prepared for but cancelled can be reported by its usual procedure number and the addition of modifier 73. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
93 Synchronous telemedicine service rendered via telephone or other real-time interactive audio-only telecommunications system : synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located away at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that is sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
AF Specialty physician
AI Principal physician of record
AM Physician, team member service
AR Physician provider services in a physician scarcity area
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CA Procedure payable only in the inpatient setting when performed emergently on an outpatient who expires prior to admission
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CG Policy criteria applied
ET Emergency services
FS Split (or shared) evaluation and management visit
GB Claim being re-submitted for payment because it is no longer covered under a global payment demonstration
GE This service has been performed by a resident without the presence of a teaching physician under the primary care exception
GL Medically unnecessary upgrade provided instead of non-upgraded item, no charge, no advance beneficiary notice (abn)
GT Via interactive audio and video telecommunication systems
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GX Notice of liability issued, voluntary under payer policy
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
KV Dmepos item subject to dmepos competitive bidding program that is furnished as part of a professional service
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
P3 A patient with severe systemic disease
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
PN Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q0 Investigational clinical service provided in a clinical research study that is in an approved clinical research study
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q3 Live kidney donor surgery and related services
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QJ Services/items provided to a prisoner or patient in state or local custody, however the state or local government, as applicable, meets the requirements in 42 cfr 411.4 (b)
QS Monitored anesthesia care service
QX Crna service: with medical direction by a physician
QZ Crna service: without medical direction by a physician
RT Right side (used to identify procedures performed on the right side of the body)
SQ Item ordered by home health
SU Procedure performed in physician's office (to denote use of facility and equipment)
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
UA Medicaid level of care 10, as defined by each state
UB Medicaid level of care 11, as defined by each state
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
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2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2014-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
Pre-1990 Added Code added.
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