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Official Description

Esophagogastroduodenoscopy, flexible, transoral; with transendoscopic ultrasound-guided transmural injection of diagnostic or therapeutic substance(s) (eg, anesthetic, neurolytic agent) or fiducial marker(s) (includes endoscopic ultrasound examination of the esophagus, stomach, and either the duodenum or a surgically altered stomach where the jejunum is examined distal to the anastomosis)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Esophagogastroduodenoscopy (EGD) is a diagnostic and therapeutic procedure that involves the use of a flexible endoscope to visualize the upper gastrointestinal tract, which includes the esophagus, stomach, and duodenum. This procedure is particularly significant when combined with transendoscopic ultrasound (EUS) for the purpose of performing transmural injections of various substances or placing fiducial markers. The term "transmural" refers to the injection of substances through the wall of the gastrointestinal tract, which can be crucial for treating conditions such as pancreatic cancer or pancreatitis. The procedure allows for the direct delivery of therapeutic agents, such as chemotherapeutic drugs, to tumors located in the pancreas or liver, or for neurolysis of the celiac plexus to alleviate pain. Additionally, fiducial markers are strategically placed to delineate tumor borders for future radiotherapy, enhancing the precision of treatment. The procedure begins with the introduction of the endoscope through the mouth, allowing for a thorough examination of the oropharynx and hypopharynx, and continues through the esophagus into the stomach and duodenum. The use of ultrasound imaging during the procedure aids in assessing the gastrointestinal wall and surrounding structures, ensuring accurate identification of tumors and their relationship to vital organs. This comprehensive approach not only facilitates diagnosis but also enables targeted therapeutic interventions, making it a vital tool in the management of gastrointestinal malignancies.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure is indicated for various conditions and symptoms that necessitate direct visualization and intervention within the upper gastrointestinal tract. The following are the primary indications for performing esophagogastroduodenoscopy with transendoscopic ultrasound-guided transmural injection:

  • Neurolysis of the celiac plexus - This is performed in patients with pancreatic cancer or pancreatitis to provide pain control.
  • Injection of chemotherapeutic agents - This is indicated for tumors located in the pancreas and liver, as well as substromal tumors of the gastrointestinal tract.
  • Placement of fiducial markers - This is commonly done for luminal and extraluminal gastrointestinal tumors, particularly pancreatic tumors, to assist in radiotherapy planning.

2. Procedure

The procedure involves several detailed steps to ensure effective diagnosis and treatment. The following outlines the procedural steps:

  • Step 1: Introduction of the endoscope - The flexible endoscope is introduced through the patient's mouth, allowing for the examination of the oropharynx and hypopharynx. As the endoscope reaches the cricopharyngeus, the patient is instructed to burp or swallow to facilitate the passage of the scope.
  • Step 2: Advancement through the gastrointestinal tract - The endoscope is advanced through the entire length of the esophagus into the stomach, passing through the pylorus and into the duodenum. During this phase, the mucosal surfaces of the duodenum and stomach are inspected as the endoscope is withdrawn. In cases where the stomach has been surgically altered, the jejunum may be examined if it is anastomosed to the stomach.
  • Step 3: Introduction of the radial scanning echoendoscope - A radial scanning echoendoscope is introduced and advanced under direct visualization. This allows for ultrasound imaging to evaluate the wall of the gastrointestinal tract and any structures within the abdominal or thoracic cavity.
  • Step 4: Tumor evaluation - Ultrasound imaging is utilized to determine the origin of any tumors, assessing whether they arise from the gastrointestinal tract or surrounding tissues, and to check for invasion into vital structures.
  • Step 5: Introduction of the linear scanning echoendoscope - After identifying the tumors, the radial scanning echoendoscope is removed, and a linear scanning echoendoscope is introduced. A fine needle injection catheter is then introduced through the surgical channel of the echoendoscope.
  • Step 6: Injection of therapeutic substances - Doppler imaging is performed to ensure that no vascular structures obstruct the planned injection route. The needle is advanced through the wall of the stomach or intestine, allowing for the injection of the therapeutic substance, typically a chemotherapeutic agent. Alternatively, a neurolytic substance may be injected into the celiac plexus for pain management.
  • Step 7: Placement of fiducial markers - If the procedure is being performed to place fiducial markers, these markers are delivered through the wall of the stomach or intestine and positioned at strategic sites to delineate tumor borders and critical structures for planned radiotherapy treatments.

3. Post-Procedure

Post-procedure care involves monitoring the patient for any immediate complications that may arise from the esophagogastroduodenoscopy and the injections performed. Patients may experience some discomfort or soreness in the throat due to the endoscope's passage. It is essential to observe for any signs of bleeding, infection, or adverse reactions to the injected substances. Recovery time may vary depending on the extent of the procedure and the patient's overall health. Patients are typically advised to refrain from eating or drinking until the effects of sedation have worn off and they can swallow safely. Follow-up appointments may be scheduled to assess the effectiveness of the treatment and to monitor the patient's condition.

Short Descr EGD US TRANSMURAL INJXN/MARK
Medium Descr EGD US GUIDED TRANSMURAL INJXN/FIDUCIAL MARKER
Long Descr Esophagogastroduodenoscopy, flexible, transoral; with transendoscopic ultrasound-guided transmural injection of diagnostic or therapeutic substance(s) (eg, anesthetic, neurolytic agent) or fiducial marker(s) (includes endoscopic ultrasound examination of the esophagus, stomach, and either the duodenum or a surgically altered stomach where the jejunum is examined distal to the anastomosis)
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 43235  Esophagogastroduodenoscopy, flexible, transoral; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8B - Endoscopy - upper gastrointestinal
MUE 1
GC This service has been performed in part by a resident under the direction of a teaching physician
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
CR Catastrophe/disaster related
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
SG Ambulatory surgical center (asc) facility service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2014-01-01 Added Added
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