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Official Description

Injection(s), anesthetic agent(s) and/or steroid; vagus nerve

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 64408 involves the injection of anesthetic agents and/or steroids into the vagus nerve, which is also known as cranial nerve X (CN X). This nerve is classified as a mixed nerve, meaning it has both motor and sensory functions. It extends from the brainstem to various organs in the body, playing a crucial role in autonomic control of the heart, lungs, and digestive tract. The vagus nerve originates in the medulla oblongata and exits the skull through the jugular foramen, branching out to innervate structures such as the pharynx, larynx, respiratory tract, heart, stomach, small intestine, and most of the large intestine, as well as the gallbladder. The injection, often referred to as a nerve block, can serve both diagnostic and therapeutic purposes, helping to alleviate pain or other symptoms associated with vagus nerve dysfunction. The procedure involves careful anatomical consideration and precise technique to ensure the correct placement of the needle and the effective delivery of the anesthetic or steroid solution.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The injection of anesthetic agents and/or steroids into the vagus nerve is indicated for various conditions that may benefit from modulation of vagal nerve activity. These indications include:

  • Pain Management The procedure may be performed to alleviate pain associated with conditions such as migraines, cluster headaches, or other types of chronic pain that may be influenced by vagal nerve activity.
  • Gastrointestinal Disorders Conditions such as gastroparesis or severe gastroesophageal reflux disease (GERD) may warrant this intervention to help manage symptoms and improve gastrointestinal motility.
  • Cardiovascular Issues The vagus nerve plays a role in heart rate regulation; therefore, this injection may be indicated for patients experiencing arrhythmias or other heart-related issues.
  • Respiratory Conditions The procedure may be indicated for patients with respiratory disorders where vagal nerve modulation could provide therapeutic benefits.

2. Procedure

The procedure for injecting anesthetic agents and/or steroids into the vagus nerve involves several critical steps to ensure accuracy and safety. The following procedural steps are outlined:

  • Step 1: Preparation The skin over the styloid process of the temporal bone is thoroughly cleansed to minimize the risk of infection. This step is crucial for maintaining a sterile environment during the injection.
  • Step 2: Needle Insertion A needle is carefully advanced until it encounters the styloid process. This anatomical landmark is essential for guiding the needle to the correct location for the injection.
  • Step 3: Needle Positioning Once the styloid process is located, the needle is retracted slightly and repositioned to follow a slightly inferior trajectory. This adjustment is necessary to ensure that the needle is directed toward the vagus nerve.
  • Step 4: Depth Advancement The needle is advanced further in this new position until it is approximately 0.5 cm deeper than the initial point of contact with the styloid process. This depth is critical for reaching the vagus nerve effectively.
  • Step 5: Aspiration Check Positioning is verified by aspiration; the practitioner checks for the presence of blood or cerebrospinal fluid. If no such fluids are aspirated, it indicates that the needle is correctly placed.
  • Step 6: Injection Once proper placement is confirmed, the anesthetic agent or steroid is injected into the targeted area, providing the intended therapeutic effect.

3. Post-Procedure

After the injection procedure, patients may be monitored for any immediate adverse reactions or complications. It is essential to observe for signs of infection, bleeding, or any neurological deficits. Patients may experience temporary relief from symptoms, but the duration and effectiveness of the treatment can vary. Follow-up appointments may be scheduled to assess the efficacy of the injection and determine if additional treatments are necessary. Patients are typically advised on post-procedure care, which may include rest and avoiding strenuous activities for a specified period to ensure optimal recovery.

Short Descr NJX AA&/STRD VAGUS NRV
Medium Descr INJECTION AA&/STRD VAGUS NERVE
Long Descr Injection(s), anesthetic agent(s) and/or steroid; vagus nerve
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5E - Ambulatory procedures - other
MUE 1
CCS Clinical Classification 9 - Other OR therapeutic nervous system procedures

This is a primary code that can be used with these additional add-on codes.

77002 CPT Add On MPFS Status: Active Code APC N ASC N1 Physician Quality Reporting CPT Assistant Article Fluoroscopic guidance for needle placement (eg, biopsy, aspiration, injection, localization device) (List separately in addition to code for primary procedure)
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
GC This service has been performed in part by a resident under the direction of a teaching physician
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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Action
Notes
2020-01-01 Changed Code description changed.
2011-01-01 Changed Short description changed.
Pre-1990 Added Code added.
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