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Official Description

Injection(s), anesthetic agent(s) and/or steroid; transforaminal epidural, with imaging guidance (fluoroscopy or CT), lumbar or sacral, each additional level (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 64484 refers to the procedure of administering injection(s) of anesthetic agent(s) and/or steroids via a transforaminal epidural approach, specifically with the aid of imaging guidance such as fluoroscopy or computed tomography (CT). This procedure is performed at the lumbar or sacral regions of the spine and is designated as an additional level injection, meaning it is billed separately in conjunction with a primary procedure. The transforaminal epidural injection is a targeted method that allows for precise delivery of medication around a specific nerve root, which is crucial for alleviating pain and inflammation associated with various spinal conditions. The foramina are small openings located between the vertebrae through which nerve roots exit the spinal canal, making them ideal sites for intervention. The process begins with the cleansing and preparation of the skin over the affected vertebra, followed by the careful advancement of a needle into the foramen under imaging guidance. This technique may involve the use of radiopaque contrast material to ensure accurate needle placement, enhancing the visibility of the procedure. Once the needle is correctly positioned, the anesthetic and/or steroid is injected around the nerve root to provide therapeutic relief. It is important to note that CPT® Code 64484 is utilized for each additional level injected beyond the primary procedure, which is coded separately under CPT® Code 64483.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The transforaminal epidural injection procedure, represented by CPT® Code 64484, is indicated for various conditions that involve nerve root irritation or inflammation. These indications may include:

  • Radiculopathy - A condition characterized by pain, weakness, or numbness that radiates along the path of a nerve due to compression or irritation.
  • Herniated Disc - The displacement of disc material that can press on nerve roots, leading to pain and neurological symptoms.
  • Spinal Stenosis - A narrowing of the spinal canal that can compress nerve roots and cause pain or discomfort.
  • Degenerative Disc Disease - A condition where the intervertebral discs lose hydration and elasticity, potentially leading to nerve root irritation.

2. Procedure

The transforaminal epidural injection procedure involves several key steps to ensure accurate delivery of the anesthetic and/or steroid medication. The steps are as follows:

  • Step 1: Patient Preparation - The patient is positioned comfortably, and the skin over the affected lumbar or sacral vertebra is thoroughly cleansed and prepared to minimize the risk of infection.
  • Step 2: Imaging Guidance - Fluoroscopy or CT imaging is utilized to visualize the anatomy and guide the needle placement accurately. This imaging is crucial for ensuring that the needle is directed towards the foramen where the nerve root exits the spinal canal.
  • Step 3: Needle Insertion - A needle is carefully advanced through the skin and into the foramen under continuous imaging guidance. This step requires precision to avoid damaging surrounding structures.
  • Step 4: Contrast Injection - A small amount of radiopaque contrast material may be injected to confirm the correct placement of the needle. This step enhances the visibility of the procedure on imaging and ensures that the needle is positioned accurately around the nerve root.
  • Step 5: Medication Injection - Once proper needle placement is confirmed, the anesthetic agent and/or steroid is injected around the nerve root. This medication aims to reduce inflammation and alleviate pain associated with the underlying condition.

3. Post-Procedure

After the transforaminal epidural injection, patients are typically monitored for a short period to assess for any immediate adverse reactions. It is common for patients to experience some relief from pain shortly after the procedure, although the full effect of the medication may take several days to manifest. Patients are usually advised to avoid strenuous activities for a specified period and may be given instructions on pain management and follow-up care. Additionally, any specific post-procedure care instructions provided by the physician should be followed to ensure optimal recovery and effectiveness of the treatment.

Short Descr NJX AA&/STRD TFRM EPI L/S EA
Medium Descr NJX AA&/STRD TFRML EPI LUMBAR/SACRAL EA ADDL
Long Descr Injection(s), anesthetic agent(s) and/or steroid; transforaminal epidural, with imaging guidance (fluoroscopy or CT), lumbar or sacral, each additional level (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6B - Minor procedures - musculoskeletal
MUE 4
CCS Clinical Classification 5 - Insertion of catheter or spinal stimulator and injection into spinal canal

This is an add-on code that must be used in conjunction with one of these primary codes.

64483 MPFS Status: Active Code APC T ASC A2 CPT Assistant Article Illustration for Code Injection(s), anesthetic agent(s) and/or steroid; transforaminal epidural, with imaging guidance (fluoroscopy or CT), lumbar or sacral, single level
RT Right side (used to identify procedures performed on the right side of the body)
LT Left side (used to identify procedures performed on the left side of the body)
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
KX Requirements specified in the medical policy have been met
GA Waiver of liability statement issued as required by payer policy, individual case
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
SG Ambulatory surgical center (asc) facility service
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
GC This service has been performed in part by a resident under the direction of a teaching physician
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
AG Primary physician
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
CR Catastrophe/disaster related
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
73 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure prior to the administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may cancel a surgical or diagnostic procedure subsequent to the patient's surgical preparation (including sedation when provided, and being taken to the room where the procedure is to be performed), but prior to the administration of anesthesia (local, regional block(s) or general). under these circumstances, the intended service that is prepared for but cancelled can be reported by its usual procedure number and the addition of modifier 73. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
74 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure after administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may terminate a surgical or diagnostic procedure after the administration of anesthesia (local, regional block(s), general) or after the procedure was started (incision made, intubation started, scope inserted, etc). under these circumstances, the procedure started but terminated can be reported by its usual procedure number and the addition of modifier 74. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
BA Item furnished in conjunction with parenteral enteral nutrition (pen) services
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
GT Via interactive audio and video telecommunication systems
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GX Notice of liability issued, voluntary under payer policy
GZ Item or service expected to be denied as not reasonable and necessary
JW Drug amount discarded/not administered to any patient
KT Beneficiary resides in a competitive bidding area and travels outside that competitive bidding area and receives a competitive bid item
KZ New coverage not implemented by managed care
N1 Group 1 oxygen coverage criteria met
PN Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RC Right coronary artery
T1 Left foot, second digit
T5 Right foot, great toe
TL Early intervention/individualized family service plan (ifsp)
TR School-based individualized education program (iep) services provided outside the public school district responsible for the student
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
Date
Action
Notes
2022-01-01 Changed First appearance of Guideline change in codebook.
2021-06-07 Changed Guideline changed per CPT Errata. Third parenthetical note moved here from code 64455.
2021-01-01 Changed Code changed.
2013-01-01 Changed Description Changed
2011-01-01 Changed Long description revised. Medium description changed. Guideline information changed.
2000-01-01 Added First appearance in code book in 2000.
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