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Official Description

Injection(s), anesthetic agent(s) and/or steroid; intercostal nerve, each additional level (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 64421 involves the injection of anesthetic agents and/or steroids into the intercostal nerves, which are critical for providing sensation and motor function to the upper body, including the thorax and abdominal wall. This type of injection, commonly known as a nerve block, can serve both diagnostic and therapeutic purposes. The intercostal nerves are classified as mixed nerves, meaning they carry both sensory and motor fibers. They emerge from the spinal cord and exit through the intervertebral foramen, subsequently running along the ribs in the intercostal grooves. These nerves are typically accessed for injection at specific anatomical landmarks, such as the posterior axillary line or near the paraspinal muscles at the rib angle. During the procedure, the healthcare provider identifies and marks the injection site along the inferior border of the rib, ensuring precise placement. A needle is then carefully introduced beneath the rib's inferior border and advanced to the subcostal groove, where the anesthetic or steroid is administered. It is important to note that CPT® Code 64421 is used for each additional intercostal nerve level injected, following the primary procedure code, which is CPT® Code 64420 for a single intercostal nerve injection.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The injection of anesthetic agents and/or steroids into the intercostal nerves is indicated for various conditions that may cause pain or discomfort in the thoracic and abdominal regions. These indications include:

  • Chronic Pain Syndromes Conditions such as postherpetic neuralgia or chronic pain following thoracic surgery may warrant the use of intercostal nerve blocks to alleviate pain.
  • Acute Pain Management Patients experiencing acute pain due to rib fractures or other thoracic injuries may benefit from this procedure to provide immediate relief.
  • Diagnostic Evaluation The procedure can also be performed as a diagnostic measure to determine the source of pain, helping to guide further treatment options.

2. Procedure

The procedure for injecting anesthetic agents and/or steroids into the intercostal nerves involves several key steps, which are detailed below:

  • Step 1: Patient Preparation The patient is positioned comfortably, and the area of injection is cleaned and sterilized to minimize the risk of infection. The healthcare provider may also explain the procedure to the patient to ensure understanding and cooperation.
  • Step 2: Identification of Injection Sites The healthcare provider identifies the specific intercostal nerve levels that require injection. This is typically done by palpating the ribs and marking the inferior border of the ribs where the injections will be administered.
  • Step 3: Needle Insertion A needle is carefully introduced beneath the inferior border of the rib at the marked site. The provider advances the needle until it reaches the subcostal groove, ensuring that the needle is positioned correctly to target the intercostal nerve.
  • Step 4: Injection of Anesthetic or Steroid Once the needle is in the appropriate position, the anesthetic agent and/or steroid is injected. The provider may aspirate the syringe to check for blood return, confirming that the needle is not in a blood vessel before proceeding with the injection.
  • Step 5: Post-Injection Care After the injection, the needle is withdrawn, and pressure may be applied to the injection site to minimize bleeding. The patient is monitored for any immediate adverse reactions before being discharged.

3. Post-Procedure

Following the injection of anesthetic agents and/or steroids into the intercostal nerves, patients may experience varying degrees of relief from pain. It is common for patients to be monitored for a short period to observe for any immediate side effects or complications, such as bleeding or infection at the injection site. Patients are typically advised to avoid strenuous activities for a short period following the procedure to allow for proper healing. Additionally, they may be instructed on signs of complications to watch for, such as increased pain, swelling, or signs of infection. Follow-up appointments may be scheduled to assess the effectiveness of the injection and to determine if further treatment is necessary.

Short Descr NJX AA&/STRD NTRCOST NRV EA
Medium Descr INJECTION AA&/STRD INTERCOSTAL NRV EA ADDL LVL
Long Descr Injection(s), anesthetic agent(s) and/or steroid; intercostal nerve, each additional level (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 4
CCS Clinical Classification 8 - Other non-OR or closed therapeutic nervous system procedures

This is an add-on code that must be used in conjunction with one of these primary codes.

64420 MPFS Status: Active Code APC T ASC A2 CPT Assistant Article Injection(s), anesthetic agent(s) and/or steroid; intercostal nerve, single level
77002 CPT Add On MPFS Status: Active Code APC N ASC N1 Physician Quality Reporting CPT Assistant Article Fluoroscopic guidance for needle placement (eg, biopsy, aspiration, injection, localization device) (List separately in addition to code for primary procedure)
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
GC This service has been performed in part by a resident under the direction of a teaching physician
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
F8 Right hand, fourth digit
G5 Most recent urr reading of 75 or greater
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SG Ambulatory surgical center (asc) facility service
T8 Right foot, fourth digit
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
Date
Action
Notes
2020-01-01 Changed Code description changed.
2011-01-01 Changed Medium description changed. Short description changed.
Pre-1990 Added Code added.
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