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Official Description

Anthrax vaccine, for subcutaneous or intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90581 refers to the anthrax vaccine, which can be administered either subcutaneously or intramuscularly. Vaccines, unlike immune globulins that offer short-term, passive immunity, are designed to provide active, long-term immunity. This is achieved by introducing altered versions of specific pathogens, such as viruses or bacteria, into the recipient's immune system. This exposure prompts the immune system to produce its own antibodies, enabling the body to recognize and combat the actual pathogen in future encounters. Anthrax, the disease targeted by this vaccine, is caused by the bacterium Bacillus anthracis and its spores. The inhalation of anthrax spores can lead to a fatal form of the disease, resulting in pneumonia, while the cutaneous form, which manifests through skin contact, is more prevalent among humans. It is important to note that this code specifically reports the anthrax vaccine product used, without including any additional services or procedures associated with its administration.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The anthrax vaccine is indicated for individuals who may be at risk of exposure to Bacillus anthracis, particularly in occupational settings or during outbreaks. The following conditions or situations may warrant the administration of the anthrax vaccine:

  • Occupational Exposure: Individuals working in laboratories that handle anthrax or in industries where exposure to anthrax spores is possible.
  • Military Personnel: Members of the armed forces who may be deployed to areas where anthrax is a potential biological threat.
  • Post-Exposure Prophylaxis: Individuals who have been exposed to anthrax spores, particularly in the inhalational form, may receive the vaccine as part of a comprehensive post-exposure prophylaxis strategy.

2. Procedure

The administration of the anthrax vaccine involves several key procedural steps to ensure safety and efficacy. The following outlines the procedure:

  • Step 1: Patient Assessment Before administering the vaccine, a thorough assessment of the patient’s medical history and potential allergies is conducted. This includes reviewing any previous reactions to vaccines and determining if the patient is currently experiencing any acute illnesses that may contraindicate vaccination.
  • Step 2: Preparation of the Vaccine The anthrax vaccine is prepared according to the manufacturer's guidelines. This includes checking the expiration date, ensuring proper storage conditions, and shaking the vial gently to mix the vaccine if necessary.
  • Step 3: Administration The vaccine can be administered either subcutaneously or intramuscularly, depending on the specific guidelines provided for the vaccine formulation. The injection site is cleaned with an antiseptic, and the vaccine is injected using a sterile syringe and needle. Proper technique is essential to minimize discomfort and ensure the vaccine is delivered effectively.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is typically done in a clinical setting where medical assistance is readily available if needed.

3. Post-Procedure

Following the administration of the anthrax vaccine, patients are advised to monitor for any side effects, which may include mild pain or swelling at the injection site, fever, or fatigue. It is important for patients to report any unusual or severe reactions to their healthcare provider. Additionally, patients may receive information regarding follow-up doses if required, as the anthrax vaccination schedule may include multiple doses for optimal immunity. Documentation of the vaccination should be recorded in the patient's medical record, including the date of administration, the vaccine lot number, and the site of injection.

Short Descr ANTHRAX VACCINE SC OR IM
Medium Descr ANTHRAX VACCINE SUBCUTANEOUS/IM USE
Long Descr Anthrax vaccine, for subcutaneous or intramuscular use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
ASC Payment Indicator
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2012-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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