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The CPT® Code 85337 refers to a laboratory test specifically designed to measure thrombomodulin, which is a glycoprotein found on the surface of endothelial cells. Thrombomodulin plays a critical role in the regulation of blood coagulation by acting as a cofactor for thrombin, which is an enzyme that converts fibrinogen into fibrin, a key component of blood clots. When thrombomodulin binds to thrombin, it facilitates the activation of protein C, leading to the initiation of an important anticoagulant pathway that helps to prevent excessive clotting. Additionally, thrombomodulin has a role in down-regulating thrombin formation, thereby contributing to the control of the coagulation process and limiting the inflammatory response in the body. Elevated levels of thrombomodulin can indicate various pathological conditions, including vascular damage, acute infections, sepsis, and other inflammatory states. The test is performed on a blood sample, which is obtained through a venipuncture procedure that is reported separately. The analysis of thrombomodulin levels is typically conducted using an enzyme-linked immunosorbent assay (ELISA), a common laboratory technique that allows for the sensitive detection and quantification of proteins in biological samples. This test is valuable for clinicians in assessing the coagulation status of patients and understanding the underlying mechanisms of various diseases.
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The thrombomodulin test (CPT® Code 85337) is indicated for the evaluation of various clinical conditions where the regulation of coagulation and inflammation is of concern. The following conditions may warrant the performance of this test:
The procedure for measuring thrombomodulin involves several key steps that ensure accurate results. First, a blood sample is obtained from the patient through a venipuncture, which is a standard method for collecting blood. This step is crucial as it provides the necessary specimen for testing. The venipuncture should be performed using aseptic techniques to minimize the risk of contamination and ensure the integrity of the sample. Once the blood is collected, it is processed in the laboratory for analysis.
After the thrombomodulin test is performed, there are generally no specific post-procedure care requirements for the patient, as the venipuncture site may be bandaged to prevent bleeding. Patients are typically advised to apply pressure to the site for a few minutes to minimize bruising. The results of the test will be interpreted by the healthcare provider in the context of the patient's overall clinical picture, and any necessary follow-up or additional testing will be determined based on the findings. It is important for healthcare professionals to communicate the results to the patient and discuss any implications for their health and treatment plan.
| Short Descr | THROMBOMODULIN | Medium Descr | THROMBOMODULIN | Long Descr | Thrombomodulin | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
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| 1993-01-01 | Added | First appearance in code book in 1993. |
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