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Code deleted. See 91318, 91319, 91320, 91321, 91322.

Official Description

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 10 mcg/0.2 mL dosage, diluent reconstituted, tris-sucrose formulation, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 91307 refers to a specific vaccine designed to provide immunity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine utilizes a formulation of messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), specifically designed to deliver the genetic instructions for producing the spike protein of the virus. The spike protein is a critical component that the virus uses to enter human cells, and by introducing this protein into the body, the vaccine prompts an immune response. The immune system recognizes the spike protein as foreign, leading to the production of antibodies that can neutralize the virus upon future exposure. The vaccine is preservative-free and is administered intramuscularly in a dosage of 10 mcg per 0.2 mL. It is important to note that this particular code is used to report the supply of the Pfizer two-dose pediatric vaccine and booster, specifically for children aged 5 to 11 years, with an additional third dose available for immunocompromised individuals. The preparation of the vaccine involves diluting it with preservative-free normal saline to achieve the correct dosage, distinguishing it from the adult formulation, which is a ready-to-use TRIS/sucrose formulation that includes buffering agents to stabilize the product and maintain pH levels. The actual injection of the vaccine is reported separately using the appropriate administration code, which varies based on the dose administered.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The vaccine coded under CPT® 91307 is indicated for the prevention of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is specifically designed for use in pediatric populations, particularly children aged 5 to 11 years, including those who are immunocompromised and may require a third dose for enhanced protection.

  • COVID-19 Prevention The vaccine is intended to provide immunity against COVID-19, reducing the risk of severe illness, hospitalization, and death associated with the disease.
  • Pediatric Use This vaccine is specifically formulated for children aged 5-11 years, addressing the unique dosing requirements for this age group.
  • Immunocompromised Patients A third dose is available for children who are immunocompromised, ensuring they receive adequate protection against the virus.

2. Procedure

The administration of the vaccine involves several key procedural steps to ensure safety and efficacy. First, the vaccine must be prepared by diluting the concentrated vaccine with preservative-free normal saline to achieve the appropriate dosage of 10 mcg per 0.2 mL. This preparation is crucial as it ensures that the vaccine is safe for pediatric use and meets the specific dosing requirements for children. Next, the healthcare provider must verify the patient's eligibility for vaccination, including confirming the patient's age and any relevant medical history, particularly for immunocompromised individuals who may require a third dose. Once the vaccine is prepared and the patient is deemed eligible, the healthcare provider will administer the vaccine via intramuscular injection, typically into the deltoid muscle of the upper arm. It is essential to follow proper injection techniques to minimize discomfort and ensure the vaccine is delivered effectively. After the injection, the patient should be monitored for a brief period to observe for any immediate adverse reactions, which is a standard practice for vaccine administration. This monitoring period allows healthcare providers to respond promptly to any potential allergic reactions or side effects.

  • Step 1: Vaccine Preparation Dilute the concentrated vaccine with preservative-free normal saline to achieve a dosage of 10 mcg per 0.2 mL.
  • Step 2: Patient Verification Confirm the patient's eligibility for vaccination, including age and medical history.
  • Step 3: Vaccine Administration Administer the vaccine intramuscularly into the deltoid muscle, following proper injection techniques.
  • Step 4: Post-Injection Monitoring Monitor the patient for any immediate adverse reactions following the vaccination.

3. Post-Procedure

After the administration of the vaccine, patients are typically advised to remain in the healthcare setting for a short observation period to monitor for any immediate side effects or allergic reactions. Common post-vaccination reactions may include mild pain at the injection site, fatigue, headache, muscle pain, chills, fever, or joint pain, which are generally self-limiting and resolve within a few days. Patients and caregivers should be provided with information regarding potential side effects and the importance of completing the vaccination series, if applicable. Additionally, they should be informed about the need for follow-up appointments for subsequent doses, especially for those receiving the two-dose series or the third dose for immunocompromised individuals. It is also essential to encourage patients to report any unusual or severe reactions to their healthcare provider, ensuring that any adverse events are documented and addressed appropriately. Overall, the post-procedure care focuses on monitoring for reactions and ensuring the patient understands the importance of follow-up care and vaccination completion.

Short Descr SARSCOV2 VAC 10 MCG TRS-SUCR
Medium Descr SARSCOV2 VACCINE 10MCG/0.2ML TRIS-SUCROSE IM USE
Long Descr Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 10 mcg/0.2 mL dosage, diluent reconstituted, tris-sucrose formulation, for intramuscular use
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
Date
Action
Notes
2025-01-01 Deleted First appearance of code deletion in codebook.
2024-01-01 Note First appearance of 2022 AMA guideline updates in codebook.
2023-11-01 Deleted Code deleted. See 91318, 91319, 91320, 91321, 91322.
2023-04-18 Note Changes made to dosing information.
2023-04-18 Note These codes (included in the guidelines) are no longer authorized for use in the United States: 0001A, 0002A, 0003A, 0004A, 0051A, 0052A, 0053A, 0054A, 0071A, 0072A, 0073A, 0074A, 0081A, 0082A, 0083A.
2023-04-18 Note AMA guideline changed to include 0121A, 0151A, 0171A, & 0172A. Published to website 2023-05-01. Received FDA approval effective retroactively to 2023-04-18.
2023-04-18 Note No longer authorized for use in the United States.
2023-03-14 Note AMA guideline changed to include 0174A. Published to website 2023-03-17. Received FDA approval effective retroactively to 2023-03-14.
2023-01-01 Added First appearance in codebook.
2022-12-08 Note AMA guideline changed to include 0173A. Published to website 2021-12-09. Received FDA approval effective retroactively to 2022-12-08.
2022-10-12 Note Ama guideline changed. 0154A recieved FDA approval.
2022-08-31 Note Ama guideline changed. 0124A recieved FDA approval immediately.
2022-08-31 Note AMA guideline changed to include 0124A, 0154A effective upon receiving emergency Use Authorization or approval from the FDA.
2022-08-31 Note Changes made to vaccine name, product & dosing information, & patient age (5-11).
2022-06-17 Note AMA Guideline changed. 0081A, 0082A, 0083A received FDA approval.
2022-06-07 Note AMA guideline changed to include 0083A effective upon receiving emergency Use Authorization or approval from the FDA.
2022-05-17 Note AMA Guideline changed. 0074A, received FDA approval.
2022-04-26 Note AMA guideline changed to include 0074A effective upon receiving emergency Use Authorization or approval from the FDA.
2022-02-01 Note AMA guideline changed to include 0081A, 0082A effective upon receiving emergency Use Authorization or approval from the FDA.
2022-01-03 Note AMA guideline changed to include 0073A FDA approval received 2022-01-12. Effective retroactively to 2022-08-31.
2021-10-29 Note Ama guideline changed. 0051A, 0052A, 0053A, 0054A, 0071A, 0072A received FDA approval
2021-10-29 Added FDA approval received for 91307.
2021-10-06 Note AMA guideline added. Includes 0001A, 0002A, 0003A, 0004A; published to website & received FDA approval prior to addition of 91307.
2021-10-06 Note AMA guideline added. Includes 0051A, 0052A, 0053A, 0054A; Published on AMA website prior to addition of 91307. Effective upon receiving Emergency Use Authorization or approval from the FDA.
2021-10-06 Note AMA guideline includes 0071A, 0072A effective upon receiving emergency Use Authorization or approval from the FDA.
2021-10-06 Added Published on AMA website. Effective upon receiving Emergency Use Authorization or approval from the Food and Drug Administration.
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