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Code deleted. See 91318, 91319, 91320, 91321, 91322.

Official Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, bivalent, preservative free, 25 mcg/0.25 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 91314 refers to a specific vaccine designed to provide immunity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the disease known as coronavirus disease (COVID-19). This vaccine utilizes a bivalent formulation, meaning it contains messenger RNA (mRNA) components that correspond to both the original strain of the virus and a variant associated with the omicron lineage, specifically targeting the BA.4 and BA.5 subvariants. The vaccine is preservative-free and is administered in a dosage of 25 mcg per 0.25 mL via intramuscular injection. The mRNA is encapsulated in lipid nanoparticles (LNP), which facilitate the delivery of the genetic material into the body's cells. Once inside, the cells utilize the mRNA as a template to produce the spike protein found on the surface of the coronavirus. This process triggers an immune response, prompting the body to generate antibodies that can recognize and combat the virus if encountered in the future. The administration of this vaccine is particularly aimed at individuals aged 6 through 11 years who have previously received COVID-19 vaccinations, serving as a booster to enhance their immune protection against the virus. It is important to note that while this code reports the supply of the vaccine, the actual injection procedure is documented separately using the appropriate administration code.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 91314 is indicated for the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically for individuals who are at risk of contracting coronavirus disease (COVID-19). The vaccine is particularly recommended for:

  • Individuals aged 6 through 11 years who have already been vaccinated against COVID-19, as a booster to enhance their immune response.

2. Procedure

The administration of the COVID-19 vaccine coded under CPT® 91314 involves several key procedural steps that ensure the vaccine is delivered effectively and safely. The following steps outline the procedure:

  • Step 1: Preparation of the Vaccine The vaccine must be prepared according to the manufacturer's guidelines. This includes ensuring that the vaccine is at the appropriate temperature and that it is mixed properly if required. The healthcare provider should verify the expiration date and inspect the vial for any particulate matter or discoloration before use.
  • Step 2: Patient Assessment Prior to administration, the healthcare provider should conduct a thorough assessment of the patient’s medical history, including any previous allergic reactions to vaccines, current medications, and overall health status. This assessment helps to identify any contraindications to the vaccine.
  • Step 3: Administration of the Vaccine The vaccine is administered via intramuscular injection, typically in the deltoid muscle of the upper arm. The provider should use a sterile syringe and needle, and the injection site should be cleaned with an alcohol swab to minimize the risk of infection. The vaccine is injected slowly and steadily to ensure proper delivery.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient should be monitored for a short period, usually 15 to 30 minutes, to observe for any immediate adverse reactions. This monitoring is crucial, especially for individuals with a history of allergies.

3. Post-Procedure

Following the administration of the COVID-19 vaccine, patients may experience mild side effects, which are common and typically resolve within a few days. These may include soreness at the injection site, fatigue, headache, muscle pain, chills, fever, or nausea. Patients should be advised to rest and hydrate adequately. It is also important to inform them about the signs of any severe allergic reactions, such as difficulty breathing or swelling of the face and throat, and to seek immediate medical attention if these occur. Additionally, patients should be encouraged to keep their vaccination records updated and to follow any recommended guidelines for subsequent doses or boosters as advised by healthcare professionals.

Short Descr SARSCOV2 VAC BVL 25MCG/.25ML
Medium Descr SARSCOV2 VACCINE BIVALENT 25 MCG/0.25 ML IM USE
Long Descr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, bivalent, preservative free, 25 mcg/0.25 mL dosage, for intramuscular use
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
SL State supplied vaccine
Date
Action
Notes
2025-01-01 Deleted First appearance of code deletion in codebook.
2024-01-01 Added First appearance in codebook.
2023-11-01 Deleted Code deleted. See 91318, 91319, 91320, 91321, 91322.
2023-04-18 Note Changes made to patient age and dosing information
2022-12-08 Note AMA Guideline changed. 0164A received FDA approval.
2022-11-16 Note AMA guideline changed to include 0164A effective upon receiving Emergency Use Authorization or approval from the FDA
2022-10-12 Added Received FDA approval.
2022-10-12 Note AMA Guideline changed. 0134A (12–17 yrs) & 0144A received FDA approval.
2022-08-31 Added Published on AMA website. Effective upon receiving EUA or approval from FDA.
2022-08-31 Note AMA guideline codes 0134A (18 yrs & older) published to website. Received FDA approval effective immediately.
2022-08-31 Note AMA guideline codes 0144A published to website. Effective upon receiving emergency Use Authorization or approval from the FDA.
2022-08-31 Note AMA guideline added. Codes 0011A, 0012A, 0013A, 0064A, 0091A, 0092A, 0093A, 0094A, 0111A, 0112A, 0113A published to website & received FDA approval prior to the addition of 91314.
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