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Code deleted. See 91318, 91319, 91320, 91321, 91322.

Official Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 25 mcg/0.25 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 91311 refers to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, specifically designed to combat coronavirus disease (COVID-19). This vaccine utilizes a novel approach by employing messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), which is a cutting-edge technology in vaccine development. The mRNA contained in the vaccine encodes the spike protein of the SARS-CoV-2 virus, which is critical for the virus's ability to infect human cells. Upon administration, the vaccine instructs the body's cells to produce copies of this spike protein, prompting the immune system to recognize it as a foreign entity. This recognition triggers an immune response, leading to the production of antibodies that can neutralize the virus if the individual is exposed in the future. The vaccine is preservative-free and is administered in a dosage of 25 mcg per 0.25 mL via intramuscular injection. It is specifically indicated for a two-dose vaccination regimen for pediatric patients aged 6 months to 5 years, providing essential protection against the potentially severe and life-threatening effects of COVID-19 in this vulnerable age group.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 91311 is indicated for the administration of the COVID-19 vaccine in specific patient populations. The following conditions and circumstances warrant the use of this vaccine:

  • Protection Against COVID-19 The vaccine is intended to provide immunity against the SARS-CoV-2 virus, which causes coronavirus disease (COVID-19).
  • Pediatric Vaccination Specifically indicated for young children aged 6 months through 5 years, ensuring that this vulnerable population receives protection against severe illness from COVID-19.

2. Procedure

The administration of the COVID-19 vaccine under CPT® Code 91311 involves several key procedural steps that ensure the vaccine is delivered safely and effectively. Each step is crucial for the successful immunization of the patient.

  • Step 1: Preparation of the Vaccine Prior to administration, the vaccine must be prepared according to the manufacturer's guidelines. This includes ensuring that the vaccine is at the appropriate temperature and that it is mixed properly if required. The healthcare provider should verify the vaccine's expiration date and ensure that it is the correct formulation for the intended patient population.
  • Step 2: Patient Assessment Before administering the vaccine, the healthcare provider should conduct a thorough assessment of the patient’s medical history, including any previous allergic reactions to vaccines, current medications, and overall health status. This assessment helps to identify any contraindications to vaccination.
  • Step 3: Administration of the Vaccine The vaccine is administered via intramuscular injection, typically in the deltoid muscle of the upper arm for older children and in the thigh for infants and toddlers. The provider should use a sterile technique, ensuring that the injection site is clean and free from contaminants. The vaccine is delivered in a dosage of 25 mcg per 0.25 mL.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient should be monitored for a short period to observe for any immediate adverse reactions. This monitoring typically lasts for 15 to 30 minutes, during which the healthcare provider can address any concerns and provide guidance on potential side effects.

3. Post-Procedure

Following the administration of the COVID-19 vaccine, patients may experience mild side effects, which are common and typically resolve within a few days. These may include soreness at the injection site, fatigue, headache, muscle pain, chills, fever, or nausea. Parents and guardians should be informed about these potential reactions and advised on how to manage them, such as using over-the-counter pain relievers if necessary. It is also important to schedule the second dose of the vaccine as per the recommended vaccination schedule to ensure full immunization. Patients should be encouraged to report any unusual or severe reactions to their healthcare provider. Additionally, ongoing education about the importance of vaccination and adherence to public health guidelines should be provided to ensure community protection against COVID-19.

Short Descr SARSCOV2 VAC 25MCG/0.25ML IM
Medium Descr SARSCOV2 VACCINE 25 MCG/0.25 ML IM USE
Long Descr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 25 mcg/0.25 mL dosage, for intramuscular use
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
Date
Action
Notes
2025-01-01 Deleted First appearance of code deletion in codebook.
2024-01-01 Note First appearance of 2022 AMA guideline changes in codebook.
2023-11-01 Deleted Code deleted. See 91318, 91319, 91320, 91321, 91322.
2023-04-18 Note 91311 and the following codes associated with it (0011A, 0012A, 0013A, 0064A, 0091A, 0092A, 0093A, 0094A, 0111A, 0112A, 0113A) are no longer authorized for use in the United States.
2023-01-01 Added First appearance in codebook.
2022-12-08 Note CPT codebook guideline(s) changed. 0164A received FDA approval.
2022-11-16 Note CPT codebook guideline(s) changed to include 0164A effective upon receiving Emergency Use Authorization or approval from the FDA
2022-10-12 Note CPT codebook guideline(s) changed. 0134A (12–17 yrs) received FDA approval.
2022-08-31 Note CPT codebook guideline(s) changed to include 0134A, 0144A effective upon receiving emergency Use Authorization or approval from the FDA.
2022-08-31 Note CPT codebook guideline(s) changed. 0134A (18 yrs & older) received FDA approval effective immediately.
2022-08-31 Note Changes made to vaccine name, product & dosing information, & patient age to (6 months through 5 years).
2022-06-17 Note CPT codebook guideline(s) changed. 0111A, 0112A, 0113A received FDA approval.
2022-06-17 Note CPT codebook guideline(s) changed. Codes 0091A, 0092A, 0093A, 0113A published on AMA website 2022-07-06. Effective retroactively to 2022-06-17
2022-06-17 Added FDA approval received
2022-05-19 Note CPT codebook guideline(s) changed to include 0111A, 0112A effective upon receiving Emergency Use Authorization or approval from the FDA.
2022-05-19 Note CPT codebook guideline(s) changed. Codes 0011A, 0012A, 0013A, 0064A, 0094A added to website & received FDA approval prior to the addition of 91311.
2022-05-19 Added Published on AMA website. Effective upon receiving EUA or approval from FDA
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