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Official Description

Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.25 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A trivalent, split virus, preservative-free influenza vaccine (IIV3) is designed for intramuscular administration. This vaccine differs from immune globulins, which offer short-term, passive immunity, as it provides active, long-term immunity. The mechanism of action involves exposing the recipient's immune system to modified versions of specific influenza viruses, prompting the immune system to generate its own antibodies. This process enables the body to "remember" how to produce these antibodies upon subsequent exposure to the same antigens. The formulation is specifically preservative-free, meaning it does not contain the preservative thimerosal or contains only trace amounts, thus classified as either thimerosal-free or thimerosal-reduced. The U.S. Food and Drug Administration (FDA) recognizes both formulations as preservative-free. The vaccine is administered via intramuscular injection, which is a separate procedure that should be reported independently. The production of the influenza vaccine involves the use of embryonated chicken eggs, where the virus is harvested, inactivated with formaldehyde, concentrated, purified, and chemically disrupted to create a split virus. This trivalent vaccine is formulated to protect against three strains of influenza viruses, specifically two different strains of influenza type A and one strain of influenza type B. For billing purposes, the CPT® code 90655 is used to report the 0.25 mL dosage of the vaccine administered intramuscularly, while code 90656 is designated for the 0.5 mL dosage. It is important to note that these codes solely represent the vaccine product utilized, and the intramuscular injection must be reported separately.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The influenza virus vaccine, trivalent (IIV3), is indicated for the prevention of influenza disease caused by the circulating strains of the virus. The vaccine is particularly recommended for individuals at higher risk of complications from influenza, including:

  • High-Risk Populations: Individuals with chronic health conditions, such as asthma, diabetes, or heart disease, who may experience severe illness if infected with the influenza virus.
  • Older Adults: Individuals aged 65 years and older, who are more susceptible to severe complications from influenza.
  • Pregnant Women: Pregnant individuals, as they are at increased risk for severe illness and can also pass antibodies to their infants.
  • Healthcare Workers: Those who work in healthcare settings to protect themselves and their patients from influenza transmission.
  • Children: Young children, especially those under the age of 5, who are at a higher risk for hospitalization due to influenza.

2. Procedure

The administration of the trivalent influenza virus vaccine involves several key procedural steps, which are outlined as follows:

  • Step 1: Preparation of the Vaccine The vaccine is prepared by ensuring that it is at the appropriate temperature and is well-mixed. This may involve gently rolling the vial to ensure uniform distribution of the vaccine components.
  • Step 2: Selection of Injection Site The healthcare provider selects an appropriate site for intramuscular injection, typically the deltoid muscle of the upper arm for adults and older children, or the anterolateral thigh for infants and young children.
  • Step 3: Administration of the Vaccine The provider cleans the injection site with an alcohol swab to reduce the risk of infection. Using a sterile syringe and needle, the vaccine is injected intramuscularly into the selected site. The needle is inserted at a 90-degree angle to ensure proper delivery into the muscle.
  • Step 4: Post-Injection Care After the injection, the provider may apply gentle pressure to the injection site with a cotton ball or gauze. The patient is monitored for a brief period to observe for any immediate adverse reactions.

3. Post-Procedure

Post-procedure care for the administration of the influenza vaccine includes monitoring the patient for any immediate side effects, which may include soreness at the injection site, low-grade fever, or mild fatigue. Patients are typically advised to remain in the healthcare setting for a short period after vaccination to ensure they do not experience any severe allergic reactions. It is also important to inform patients about potential side effects and the expected duration of these effects. Patients should be encouraged to report any unusual or severe reactions to their healthcare provider. Additionally, individuals should be advised to continue practicing preventive measures against influenza, such as hand hygiene and avoiding close contact with sick individuals, even after vaccination.

Short Descr IIV3 VACC NO PRSV 0.25 ML IM
Medium Descr IIV3 VACC PRESRV FREE 0.25 ML DOSAGE IM USE
Long Descr Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.25 mL dosage, for intramuscular use
Related Drugs FLUZONE
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
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Notes
2017-01-01 Changed Long, Medium and Short descriptions changed.
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2013-01-01 Changed Description Changed
2007-01-01 Changed Code description changed.
2004-01-01 Added First appearance in code book in 2004.
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