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Official Description

Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A trivalent live influenza virus vaccine (LAIV3) for intranasal use is designed to provide active, long-term immunity against influenza. Unlike immune globulins, which offer short-term, passive immunity, vaccines work by exposing the recipient's immune system to modified versions of specific viruses or bacteria. This exposure prompts the immune system to produce its own antibodies, enabling the body to remember how to respond to the actual virus upon future exposure. The intranasal influenza virus vaccine is classified as a live attenuated vaccine, meaning it contains a weakened form of the live influenza virus. When administered as a nasal spray, the LAIV stimulates the immune system to generate antibodies against the influenza virus. The vaccine is specifically cold-adapted and temperature-sensitive, allowing the virus to replicate only in the cooler environment of the nose and throat, thereby preventing it from spreading to the upper respiratory tract where temperatures are higher. The trivalent formulation includes two different strains of influenza type A and one strain of influenza type B, providing broad protection against circulating influenza viruses. It is important to note that this code specifically reports the vaccine product itself, and the administration of the intranasal vaccine should be reported separately.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The trivalent live influenza virus vaccine (LAIV3) is indicated for the prevention of influenza in individuals who meet specific criteria. The following conditions and circumstances warrant the administration of this vaccine:

  • Prevention of Influenza The vaccine is primarily used to protect against influenza virus infections during the flu season, particularly in populations at risk of complications from the disease.
  • Age Appropriateness The vaccine is indicated for use in healthy individuals aged 2 through 49 years, as this age group is generally more responsive to the live attenuated vaccine.
  • Public Health Recommendations The vaccine is recommended in accordance with public health guidelines to reduce the incidence of influenza and its associated complications in the community.

2. Procedure

The administration of the trivalent live influenza virus vaccine (LAIV3) involves several key procedural steps to ensure effective vaccination:

  • Step 1: Patient Assessment Prior to administration, a thorough assessment of the patient’s medical history is conducted to determine eligibility for the vaccine. This includes evaluating any contraindications, such as allergies to vaccine components or a history of severe reactions to previous influenza vaccines.
  • Step 2: Preparation of the Vaccine The LAIV3 is prepared according to the manufacturer's instructions. This includes ensuring that the vaccine is stored at the appropriate temperature and is not expired. The vaccine is typically provided in a pre-filled nasal spray device, ready for administration.
  • Step 3: Administration of the Vaccine The vaccine is administered intranasally. The patient is instructed to tilt their head slightly back, and the healthcare provider delivers the vaccine into one nostril while ensuring that the patient does not sniff or blow their nose immediately after administration to allow for optimal absorption.
  • Step 4: Post-Administration Observation After administration, the patient is monitored for a brief period to observe for any immediate adverse reactions. This is particularly important for individuals with a history of allergies or previous vaccine reactions.

3. Post-Procedure

Following the administration of the trivalent live influenza virus vaccine (LAIV3), patients are advised on post-procedure care and expected outcomes. It is common for individuals to experience mild side effects, such as nasal congestion, runny nose, or mild headache, which typically resolve within a few days. Patients should be informed that the vaccine may take up to two weeks to provide full protection against influenza. Additionally, they should be advised to report any unusual or severe reactions to their healthcare provider. It is also recommended that patients continue to practice good hygiene and follow public health guidelines to further reduce the risk of influenza transmission.

Short Descr LAIV3 VACCINE INTRANASAL
Medium Descr LAIV3 VACCINE LIVE FOR INTRANASAL USE
Long Descr Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use
Related Drugs FluMist
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2013-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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