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Official Description

Influenza virus vaccine, trivalent (ccIIV3), derived from cell cultures, subunit, antibiotic free, 0.5 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90661 refers to the influenza virus vaccine, specifically a trivalent formulation known as ccIIV3. This vaccine is derived from cell cultures and is designed to provide active, long-term immunity against influenza. Unlike immune globulins, which offer short-term, passive immunity, vaccines stimulate the recipient's immune system to produce its own antibodies. This process involves exposing the immune system to altered versions of specific viruses, prompting it to recognize and remember how to combat these pathogens in the future. The trivalent nature of this vaccine means it contains components from three different influenza viruses: two strains of influenza type A and one strain of influenza type B. A notable feature of this vaccine is that it is antibiotic-free, produced in a sterile environment without the use of antibiotics, which distinguishes it from other influenza vaccine formulations. The dosage for this vaccine is 0.5 mL, and it is intended for intramuscular use. It is important to note that the administration of this vaccine via intramuscular injection is reported separately from the vaccine code itself.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The influenza virus vaccine, CPT® Code 90661, is indicated for the prevention of influenza caused by the strains included in the vaccine formulation. The vaccine is particularly recommended for individuals at higher risk of influenza-related complications, including but not limited to:

  • High-Risk Populations Individuals such as the elderly, young children, pregnant women, and those with chronic health conditions (e.g., asthma, diabetes, heart disease) who are more susceptible to severe influenza illness.
  • Healthcare Workers Professionals who are in close contact with patients and may transmit the virus to vulnerable populations.
  • Community-Wide Vaccination General public vaccination efforts aimed at reducing the overall incidence of influenza in the community, particularly during flu season.

2. Procedure

The administration of the influenza virus vaccine, CPT® Code 90661, involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine. These steps include:

  • Step 1: Preparation Prior to administration, the healthcare provider must prepare the vaccine by ensuring it is stored correctly and is at the appropriate temperature. The vaccine should be visually inspected for any particulate matter or discoloration before use.
  • Step 2: Patient Assessment The healthcare provider should assess the patient’s medical history, including any previous allergic reactions to vaccines, current medications, and overall health status to determine eligibility for vaccination.
  • Step 3: Administration The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for adults and older children, or in the anterolateral thigh for infants and young children. The provider should use a sterile needle and syringe, and the injection site should be cleaned with an alcohol swab prior to administration.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient should be monitored for a short period (usually 15 minutes) for any immediate adverse reactions, such as allergic responses. This is particularly important for individuals with a history of allergies.

3. Post-Procedure

Following the administration of the influenza virus vaccine, patients may experience mild side effects, which are generally self-limiting. Common post-procedure care includes advising the patient to rest and hydrate, as well as monitoring for any unusual symptoms. Patients should be informed about potential side effects, such as soreness at the injection site, low-grade fever, or fatigue, which typically resolve within a few days. It is also important to remind patients that the vaccine takes about two weeks to provide optimal protection against influenza, and they should continue to practice preventive measures, such as hand hygiene and avoiding close contact with sick individuals, during this period.

Short Descr CCIIV3 VAC ABX FR 0.5 ML IM
Medium Descr CCIIV3 VACCINE ABX FREE 0.5 ML FOR IM USE
Long Descr Influenza virus vaccine, trivalent (ccIIV3), derived from cell cultures, subunit, antibiotic free, 0.5 mL dosage, for intramuscular use
Related Drugs Flucelvax
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
Date
Action
Notes
2025-01-01 Changed Short, Medium, and Long Descriptions changed.
2017-01-01 Changed Long, Medium and Short descriptions changed.
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2012-11-20 Changed Approved by FDA. Removed the 'Product Pending FDA Approval' flag.
2008-01-01 Added First appearance in codebook.
Code
Description
Code
Description
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