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Official Description

Influenza virus vaccine, trivalent (RIV3), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90673 refers to the Influenza virus vaccine, specifically a trivalent formulation known as Flublok. This vaccine is unique as it is derived from recombinant DNA technology and does not utilize the traditional influenza virus or eggs in its production. Instead, it employs an insect virus, specifically a baculovirus, to express the hemagglutinin (HA) protein, which is a critical component of the influenza virus that elicits an immune response. The trivalent nature of this vaccine means it contains three full-strength recombinant HA proteins, designed to provide immunity against two distinct strains of Influenza A and one strain of Influenza B. The administration of this vaccine is performed via intramuscular injection, and it is important to note that the reporting of the vaccine's administration is done separately from the vaccine code itself. This innovative approach to vaccine production allows for a more rapid response in the event of a pandemic influenza outbreak, as it can facilitate quicker manufacturing and larger quantities of the vaccine to be produced when necessary.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The Influenza virus vaccine, trivalent (RIV3), is indicated for the prevention of influenza caused by the strains included in the vaccine formulation. The vaccine is particularly recommended for individuals who are at higher risk of developing complications from influenza, including but not limited to:

  • High-Risk Populations: Individuals with chronic health conditions, such as asthma, diabetes, or heart disease, who may experience severe illness if infected with the influenza virus.
  • Older Adults: Seniors aged 65 years and older, who are more susceptible to influenza-related complications.
  • Healthcare Workers: Those who are in close contact with patients, particularly in healthcare settings, to help prevent the spread of influenza.
  • Pregnant Women: Pregnant individuals, as they are at increased risk for severe illness from influenza and can also pass immunity to their newborns.

2. Procedure

The administration of the Influenza virus vaccine, trivalent (RIV3), involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine. Each step is critical to the overall success of the vaccination process.

  • Step 1: Preparation of the Vaccine The vaccine should be prepared according to the manufacturer's guidelines. This includes checking the expiration date, ensuring the vaccine is stored at the correct temperature, and gently swirling the vial to mix the contents without shaking, which could damage the vaccine.
  • Step 2: Patient Assessment Prior to administration, a thorough assessment of the patient should be conducted. This includes reviewing the patient's medical history, checking for any contraindications to the vaccine, and obtaining informed consent. It is essential to ensure that the patient is not allergic to any components of the vaccine.
  • Step 3: Administration of the Vaccine The vaccine is administered via intramuscular injection, typically in the deltoid muscle of the upper arm for adults and older children, or in the anterolateral thigh for infants and young children. The injection site should be cleaned with an alcohol swab before administration to minimize the risk of infection.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient should be monitored for a short period to observe for any immediate adverse reactions. This is particularly important for individuals who may have a history of allergic reactions to vaccines.

3. Post-Procedure

Following the administration of the Influenza virus vaccine, trivalent (RIV3), patients are typically advised to remain in the healthcare setting for a brief observation period, usually around 15 minutes, to ensure they do not experience any immediate adverse effects. Common post-vaccination care includes advising patients about potential mild side effects, such as soreness at the injection site, low-grade fever, or fatigue, which are generally self-limiting. Patients should be informed to seek medical attention if they experience any severe allergic reactions, such as difficulty breathing or swelling of the face and throat. Additionally, patients may be encouraged to report any unusual symptoms or side effects to their healthcare provider. It is also important to remind patients that the vaccine does not provide immediate immunity and that it typically takes about two weeks for the body to develop protection against the influenza virus after vaccination.

Short Descr RIV3 VACCINE NO PRESERV IM
Medium Descr RIV3 VACCINE PRESERVATIVE FREE FOR IM USE
Long Descr Influenza virus vaccine, trivalent (RIV3), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use
Related Drugs FLUBLOK TRIVALENT NORTHERN HEMISPHERE
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
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Action
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2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2014-01-01 Added Added
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