CPT® Code 90666

1. Indications

The influenza virus vaccine (CPT® Code 90666) is indicated for use during pandemic situations when a new strain of the influenza virus emerges and spreads among the human population. The following conditions warrant the administration of this vaccine:

• Pandemic Influenza Outbreaks Individuals are at risk of severe illness and death due to a new influenza strain that the population has little to no immunity against.
• High-Risk Populations Individuals, particularly the elderly and those with compromised immune systems, may require vaccination to enhance their immune response against the pandemic strain.

2. Procedure

The administration of the influenza virus vaccine (CPT® Code 90666) involves several key procedural steps to ensure safety and efficacy:

• Step 1: Preparation of the Vaccine The vaccine is prepared from a split virus formulation, which involves growing the influenza virus in embryonated chicken eggs. The virus is then harvested and inactivated using formaldehyde to ensure it cannot cause disease.
• Step 2: Concentration and Purification After inactivation, the virus is concentrated using techniques that increase the antigen content, followed by purification processes to remove any impurities and ensure the vaccine's safety.
• Step 3: Chemical Disruption The concentrated virus undergoes chemical disruption to create a split virus, which enhances the immune response by presenting the virus's antigens without the risk of causing illness.
• Step 4: Administration The final vaccine product is administered via intramuscular injection, which is a standard method for delivering vaccines to ensure optimal absorption and immune response.

3. Post-Procedure

After the administration of the influenza virus vaccine (CPT® Code 90666), patients may be monitored for any immediate adverse reactions, although serious side effects are rare. Common post-procedure care includes advising patients to rest and hydrate adequately. Patients should be informed about potential mild side effects, such as soreness at the injection site, low-grade fever, or fatigue, which typically resolve within a few days. It is also important to remind patients to seek medical attention if they experience any unusual or severe reactions following vaccination. Additionally, individuals should be encouraged to continue practicing preventive measures against influenza, such as hand hygiene and avoiding close contact with sick individuals, especially during pandemic outbreaks.