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Official Description

Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A trivalent, split virus influenza vaccine (IIV3) is designed for intramuscular administration and is specifically formulated to provide active, long-term immunity against influenza. Unlike immune globulins, which offer short-term, passive immunity, this vaccine works by stimulating the recipient's immune system to recognize and combat the influenza virus. The vaccine contains altered versions of the virus, prompting the immune system to produce its own antibodies. This process enables the body to "remember" how to generate these antibodies upon future exposure to the actual virus, thereby enhancing the individual's ability to fight off influenza infections. The vaccine is produced using embryonated chicken eggs, where the influenza virus is cultivated, harvested, and inactivated with formaldehyde. The virus is then concentrated, purified, and chemically disrupted to create a split virus, which is further purified to ensure safety and efficacy. The trivalent formulation includes two distinct strains of influenza type A and one strain of influenza type B, providing broad protection against circulating influenza viruses. For billing purposes, the CPT® code 90658 is used to report the 0.5 mL dosage of this vaccine, while a separate code, 90657, is designated for a 0.25 mL dosage. It is important to note that these codes solely represent the vaccine product administered, and the intramuscular injection itself should be reported separately.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The trivalent, split virus influenza vaccine (IIV3) is indicated for the prevention of influenza in individuals who are at risk of contracting the virus. The following conditions and circumstances warrant the administration of this vaccine:

  • Seasonal Influenza Prevention Individuals seeking protection against seasonal influenza viruses, particularly during flu season.
  • High-Risk Populations Patients with underlying health conditions, such as asthma, diabetes, or heart disease, who are at increased risk for influenza-related complications.
  • Healthcare Workers Healthcare professionals who are in close contact with patients and may transmit the virus.
  • Individuals Aged 6 Months and Older The vaccine is recommended for all individuals aged 6 months and older, as they are susceptible to influenza infection.

2. Procedure

The administration of the trivalent, split virus influenza vaccine involves several key procedural steps to ensure proper delivery and effectiveness:

  • Step 1: Preparation of the Vaccine The vaccine is prepared by ensuring that it is at room temperature and gently agitated to mix the components thoroughly. This step is crucial to ensure uniform distribution of the vaccine's active ingredients.
  • Step 2: Selection of Injection Site The healthcare provider selects an appropriate site for intramuscular injection, typically the deltoid muscle of the upper arm for adults and older children, or the anterolateral thigh for infants and young children.
  • Step 3: Administration of the Vaccine Using a sterile syringe and needle, the provider administers the 0.5 mL dosage of the vaccine intramuscularly. The needle is inserted at a 90-degree angle to the skin to ensure proper delivery into the muscle tissue.
  • Step 4: Post-Administration Care After the injection, the provider may apply gentle pressure to the injection site with a cotton ball or gauze. Patients are typically monitored for a short period to observe for any immediate adverse reactions.

3. Post-Procedure

Post-procedure care following the administration of the trivalent influenza vaccine includes monitoring the patient for any immediate side effects, which may include soreness at the injection site, low-grade fever, or mild fatigue. These reactions are generally mild and resolve on their own within a few days. Patients are advised to rest and stay hydrated. It is also important to inform patients about potential delayed reactions and when to seek medical attention. Additionally, individuals should be educated on the importance of receiving the vaccine annually, as influenza viruses can change from year to year, necessitating updated vaccinations for optimal protection.

Short Descr IIV3 VACCINE SPLT 0.5 ML IM
Medium Descr IIV3 VACCINE SPLIT VIRUS 0.5 ML DOSAGE IM USE
Long Descr Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use
Related Drugs Afluria
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Influenza vaccine; pneumococcal vaccine.
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
SL State supplied vaccine
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Notes
2017-01-01 Changed Long, Medium and Short descriptions changed.
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2013-01-01 Changed Description Changed
2011-01-01 Changed Short description changed.
2008-01-01 Changed Code description changed.
2007-01-01 Changed Code description changed.
2004-01-01 Changed Code description changed.
1999-01-01 Added First appearance in code book in 1999.
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