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Official Description

Influenza virus vaccine, live (LAIV), pandemic formulation, for intranasal use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90664 refers to the influenza virus vaccine, specifically a live attenuated influenza virus (LAIV) vaccine that is formulated for intranasal use. This vaccine contains a weakened form of the live influenza virus, which is designed to stimulate the immune system without causing the disease. The pandemic formulation of this vaccine may differ from the standard interpandemic strains, incorporating specific additives known as adjuvants that enhance the immune response by increasing the antigen content. These formulations are crucial during an influenza pandemic, which occurs when a novel strain of the influenza virus emerges and spreads among the human population, often resulting in significant morbidity and mortality due to the lack of pre-existing immunity in the population. The intranasal administration of LAIV is particularly effective as it targets the mucosal immune system in the nasal passages, prompting the body to produce antibodies against the influenza virus. Notably, LAIV is cold-adapted and temperature-sensitive, meaning that it replicates effectively only in the cooler environment of the nose and throat, preventing it from spreading to the upper respiratory tract where the temperature is higher. This code is specifically designated for the vaccine product itself, and it is important to report the intranasal administration of the vaccine separately to ensure accurate billing and coding practices.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The influenza virus vaccine, live (LAIV), pandemic formulation, is indicated for use in individuals during an influenza pandemic. The primary purpose of this vaccine is to provide immunity against a new strain of the influenza virus that has emerged and is spreading within the human population. The vaccine is particularly important for individuals who may have little or no pre-existing immunity to the new strain, thereby reducing the risk of severe illness and complications associated with the outbreak.

  • Influenza Pandemic The vaccine is indicated for individuals during an influenza pandemic when a new strain of the virus is circulating.
  • Immunity Enhancement It is used to enhance the immune response in individuals who may lack immunity to the new influenza strain.

2. Procedure

The administration of the influenza virus vaccine, live (LAIV), involves specific procedural steps to ensure effective delivery and immune response. The following steps outline the procedure:

  • Step 1: Preparation Prior to administration, the vaccine should be prepared according to the manufacturer's instructions. This includes ensuring that the vaccine is stored at the appropriate temperature and is not expired.
  • Step 2: Patient Assessment A thorough assessment of the patient should be conducted to confirm eligibility for the vaccine, including reviewing any contraindications or previous adverse reactions to influenza vaccines.
  • Step 3: Administration The vaccine is administered intranasally, typically as a nasal spray. The patient is instructed to inhale the vaccine mist through their nose, which allows the live attenuated virus to stimulate the immune system effectively.
  • Step 4: Post-Administration Monitoring After administration, the patient should be monitored for a short period to observe for any immediate adverse reactions, although serious reactions are rare.

3. Post-Procedure

Post-procedure care for the administration of the LAIV vaccine includes advising the patient on potential mild side effects, which may include nasal congestion, runny nose, or mild fever. Patients should be informed that these symptoms are generally self-limiting and indicate that the immune system is responding to the vaccine. It is also important to instruct patients to report any unusual or severe reactions following vaccination. Additionally, patients should be advised to continue practicing preventive measures against influenza, such as hand hygiene and avoiding close contact with sick individuals, especially during flu season.

Short Descr LAIV VACC PANDEMIC INTRANASL
Medium Descr LAIV VACCINE PANDEMIC FORMULA FOR INTRANASAL USE
Long Descr Influenza virus vaccine, live (LAIV), pandemic formulation, for intranasal use
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2011-01-01 Added First appearance in code book
2010-07-01 Added Implemented
Code
Description
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