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Official Description

Influenza virus vaccine (IIV), pandemic formulation, split virus, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90668 refers to the influenza virus vaccine specifically formulated for pandemic situations. This vaccine is a split virus type, which means it is created using a method that involves breaking apart the virus particles to enhance the immune response without using live virus. The pandemic formulation is distinct from standard influenza vaccines, as it is designed to address new strains of the virus that can emerge during an influenza pandemic, when the population has little to no pre-existing immunity. The vaccine is administered via intramuscular injection, ensuring that it is delivered effectively into the muscle tissue for optimal absorption and immune response. The production of this vaccine involves several steps, including the cultivation of the virus in embryonated chicken eggs, inactivation of the virus with formaldehyde, concentration to increase the antigen content, and purification processes to ensure safety and efficacy. This vaccine is crucial in preventing widespread illness and mortality during a pandemic, as it helps to build immunity against the newly emerging strains of the influenza virus.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The influenza virus vaccine (CPT® Code 90668) is indicated for use during a pandemic situation when a new strain of the influenza virus emerges. The following conditions and scenarios warrant the administration of this vaccine:

  • Pandemic Influenza Outbreak The vaccine is specifically formulated to protect against new strains of the influenza virus that can lead to widespread illness and mortality.
  • Individuals with Little or No Immunity The vaccine is essential for individuals who have not been previously exposed to the new strain, as they may have little or no immunity, increasing their risk of severe illness.
  • General Population During a Pandemic The vaccine is recommended for the general population to help control the spread of the virus and reduce the impact of the pandemic.

2. Procedure

The administration of the influenza virus vaccine (CPT® Code 90668) involves several key procedural steps to ensure safety and efficacy:

  • Step 1: Preparation of the Vaccine The vaccine is prepared by harvesting the virus from embryonated chicken eggs, where it is cultivated. The harvested virus is then inactivated using formaldehyde to ensure that it cannot cause disease.
  • Step 2: Concentration and Purification After inactivation, the virus is concentrated to increase the antigen content, which is crucial for eliciting a strong immune response. This concentrated virus undergoes further purification to remove any impurities and ensure the vaccine's safety.
  • Step 3: Chemical Disruption The purified virus is chemically disrupted to create a split virus formulation. This process breaks the virus into smaller components, which helps to enhance the immune response without using live virus.
  • Step 4: Administration The final vaccine product is administered via intramuscular injection. This method ensures that the vaccine is delivered effectively into the muscle tissue, allowing for optimal absorption and immune response.

3. Post-Procedure

After the administration of the influenza virus vaccine (CPT® Code 90668), patients may experience mild side effects, which are common with vaccinations. These can include soreness at the injection site, low-grade fever, or fatigue. It is important for healthcare providers to monitor patients for any adverse reactions following the vaccination. Patients are typically advised to rest and hydrate after receiving the vaccine. The expected recovery time is generally short, with most individuals returning to normal activities shortly after vaccination. Additionally, it is essential to inform patients about the importance of receiving the vaccine during a pandemic to help protect themselves and the community from the spread of the influenza virus.

Short Descr IIV VACCINE PANDEMIC IM
Medium Descr IIV VACCINE PANDEMIC FOR INTRAMUSCULAR USE
Long Descr Influenza virus vaccine (IIV), pandemic formulation, split virus, for intramuscular use
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) V - Pneumococcal/Flu Vaccine
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed. FDA approval pending
2011-01-01 Added First appearance in code book
2010-07-01 Added Implemented
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